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A preparation method and application of nano-pesticide transported by plant phloem

A nano-pesticide and phloem technology, which is applied in the field of nano-pesticide preparation, can solve the problems of increasing the phloem transport properties of the compound, reducing the biological activity of the original drug compound, and the huge cost.

Active Publication Date: 2021-05-07
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the coupling of amino acid-directing groups to pesticide molecules significantly increases the phloem transport properties of the compounds, but also reduces the biological activity of the original drug compounds
At the same time, the transformation of the structure of the original drug results in huge costs for the development of new drugs

Method used

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  • A preparation method and application of nano-pesticide transported by plant phloem
  • A preparation method and application of nano-pesticide transported by plant phloem
  • A preparation method and application of nano-pesticide transported by plant phloem

Examples

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Embodiment 1

[0023] The present embodiment provides a kind of fludioxonil nanopesticide, and its preparation method is as follows:

[0024] Weigh 0.97 g PSI and dissolve in 10 mL DMSO solution to form a PSI solution; weigh 1.5 g arginine methyl ester hydrochloride and 1.55 g di-n-butylamine, mix them in 10 mL DMSO solution, and mix The solution was added to the PSI solution with vigorous stirring. After 6 hours of reaction, the reacted solution was added dropwise to a citric acid buffer solution with a pH of 2.5 to form a precipitate, which was centrifuged and washed three times with distilled water in a high-speed centrifuge at a speed of 10,000 r / min. Arginine methyl ester nanocarriers were obtained after lyophilization.

[0025] Weigh 100 mg of arginine methyl ester nanocarriers and 100 mg of fludioxonil, disperse them in 100 mL of aqueous solution, stir for 3 min at high speed using a high-speed shear emulsification homogenizer, and then let stand. After defoaming Add xanthan gum to ...

Embodiment 2

[0027] The present embodiment provides a kind of fludioxonil nanopesticide, and its preparation method is as follows:

[0028] Weigh 0.5 g PSI and dissolve in 10 mL DMSO solution to form a PSI solution; weigh 1 g tyrosine methyl ester hydrochloride and 1.1 g di-n-butylamine, dissolve in 10 mL DMSO solution, and mix The solution was added to the PSI solution with vigorous stirring. After 12 h of reaction, the reacted solution was added dropwise to a citric acid buffer solution with a pH of 2.5 to form a precipitate, which was centrifuged and washed three times with distilled water in a high-speed centrifuge at a speed of 10,000 r / min. The tyrosine methyl ester nanocarrier was obtained after freeze-drying.

[0029] Weigh 100 mg of tyrosine methyl ester nanocarriers and 100 mg of fludioxonil, disperse them in 50 mL of aqueous solution, stir for 3 min at high speed using a high-speed shear emulsification homogenizer, and then let stand. After defoaming Add xanthan gum to make th...

Embodiment 3

[0031] The present embodiment provides a kind of fludioxonil nanopesticide, and its preparation method is as follows:

[0032] Weigh 0.5 g PSI and dissolve in 10 mL DMSO solution to form a PSI solution; weigh 1 g serine methyl ester hydrochloride and 1.1 g di-n-butylamine, mix them in 10 mL DMSO solution, add this mixed solution Stir vigorously into the PSI solution. After 24 hours of reaction, the reacted solution was added dropwise to a citric acid buffer solution with a pH of 2.5 to form a precipitate, which was centrifuged and washed three times with distilled water in a high-speed centrifuge at a speed of 10,000 r / min. The serine methyl ester nanocarrier was obtained after lyophilization.

[0033] Weigh 200 mg of serine methyl ester nanocarriers and 100 mg of fludioxonil, disperse them in 100 mL of aqueous solution, stir for 3 min at high speed using a high-speed shear emulsification homogenizer, and then let it stand still. After defoaming, add yellow Raw gum, make the...

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Abstract

The invention belongs to the technical field of nano and pesticides, and in particular relates to a preparation method of nano pesticides conducted by plant phloem, comprising the following steps: (1) dissolving PSI in DMSO to form a PSI solution; mixing amino acid methyl ester hydrochloride with Di-n-butylamine is miscible in DMSO to form a mixed solution; (2) Add the mixed solution to the PSI solution, mix evenly, slowly add the reacted solution into the citric acid buffer, and perform centrifugation, Wash and freeze-dry to obtain nanocarriers; (3) Disperse the nanocarriers and pesticides in water according to a certain ratio, stir for 3 minutes and let stand, add xanthan gum after defoaming, emulsify and homogenize again for 1-5 minutes Stand still, after defoaming, add magnesium aluminum silicate, stir for 5 h and then stand still to obtain nano-pesticide. The invention increases the effective way of transporting and targeting the nano-pesticide in the plant phloem, and can effectively prevent and control plant diseases and insect pests.

Description

technical field [0001] The invention belongs to the technical field of nano and pesticides, and in particular relates to a preparation method and application of nano pesticides conducted by plant phloem. Background technique [0002] The extensive use of traditional pesticides has produced a series of problems, such as environmental pollution and excessive pesticide residues, which have seriously affected human survival. Nanotechnology can effectively alleviate pesticide residue pollution and improve the effective utilization of pesticides. In addition, the nano-drug loading system has the advantages of improving the stability, dispersibility, and utilization of pesticides, extending the duration of efficacy, and reducing residues. [0003] Amino acids play an important role in the growth of plants. The conduction of amino acids in plants is accomplished through conduits and sieve tubes. The content of amino acids in the phloem is 5-40 g / L, while the content of amino acids...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/90A01N43/36A01N53/08A01N25/10A01P3/00A01P1/00
CPCA01N25/10A01N43/36A01N43/90A01N53/00
Inventor 贾金亮胡鹏通吴瀚翔徐汉虹朱丽庄秀涵
Owner SOUTH CHINA AGRI UNIV
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