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A pharmaceutical composition capable of treating neurodegenerative diseases

A technology of composition and medicine, applied in the field of Chinese medicine extract combination

Active Publication Date: 2021-10-08
KUNMING MEDICAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its medicinal effects mainly relieve cough and reduce phlegm, antibacterial and anti-inflammatory, lower blood pressure and lipid, etc., but there are few reports on the pharmacological effects of neurodegenerative diseases

Method used

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  • A pharmaceutical composition capable of treating neurodegenerative diseases
  • A pharmaceutical composition capable of treating neurodegenerative diseases
  • A pharmaceutical composition capable of treating neurodegenerative diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 Preparation of Gastrodia elata extract, Sanqi extract, Shichangpu extract, Coleus forskohlii extract, and peanut shell extract

[0040] Preparation of Gastrodia elata extract: Take the qualified Gastrodia elata medicinal material, remove impurities and wash, dry at low temperature <60°C, crush and pass through a 100-mesh sieve; soak the powder in 60L of 50% ethanol / water, shake well, and let it stand overnight. The next day, 60L of solvent was poured out and filtered, and transferred to a rotary evaporator for concentration. Add the Gastrodia elata primary filter to 50% ethanol / water, transfer it to a reflux extraction tank, and reflux extraction at 85°C-90°C for 2 hours. Then concentrate the extract with a rotary evaporator until dry to obtain the Gastrodia elata extract.

[0041] Preparation of Panax notoginseng extract: Take the qualified Panax notoginseng medicinal material, remove impurities and wash, dry at low temperature <60°C, crush and pass through ...

Embodiment 2

[0046] The drug extracts obtained in Example 1 were combined to obtain a drug composition containing the following parts by weight: 30 parts of Gastrodia elata extract, 6.25 parts of Panax notoginseng extract, and 6 parts of Acorus calamus extract.

Embodiment 3

[0048] Combine the drug extracts obtained in Example 1 to obtain a drug composition containing the following parts by weight: 30 parts of Gastrodia elata extract, 6.25 parts of Panax notoginseng extract, 6 parts of Acorus calamus extract, and 2 parts of Coleus forskohlii extract .

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Abstract

The invention discloses a pharmaceutical composition capable of treating neurodegenerative diseases, which comprises the following parts by weight: 10-90 parts of Gastrodia elata extract, 10-90 parts of Sanqi extract, 10-90 parts of Shichangpu extract, Coleus forskohlii extract 10-90 parts, peanut shell extract 10-90 parts. The pharmaceutical composition of the invention has strong preventive or antagonistic effects on neurodegenerative diseases, and the pharmaceutical composition has better pharmacological activity than a single extract at the same dose.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, in particular to a combination of traditional Chinese medicine extracts capable of treating neurodegenerative diseases. Background technique [0002] Dementia is a chronic degenerative disease of the central nervous system characterized by memory impairment and cognitive dysfunction induced by multiple factors. Its main clinical manifestations are chronic memory impairment, cognitive dysfunction and personality changes, and gradually progress to severe dementia. , is a neurodegenerative disease with a high incidence in the elderly population. Dementia is divided into Alzheimer's disease (AD), vascular dementia (VaD), traumatic brain dementia, or dementia caused by poisoning, hypoxia and other factors and mixed dementia. In general, the proportion of AD in patients with onset is 50-75%, and the proportion of VaD is 5-20%. The number of people living with dementia worldwide is estimat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8988A61P25/28A23L33/10A23L33/105
CPCA23V2002/00A61K36/258A61K36/48A61K36/53A61K36/888A61K36/8988A23L33/10A23L33/105A61P25/28A61K2300/00A23V2200/322A23V2250/21A23V2300/14
Inventor 杨为民陈晨田孟华翁稚颖李鲜何海艳刘毅王玉川余显伦施蕊王红艳郑昌博宋流东
Owner KUNMING MEDICAL UNIVERSITY