A traditional Chinese medicine compound feed additive for replacing antibiotics and its preparation method and application

A feed additive and a technology to replace antibiotics, applied in the field of traditional Chinese veterinary medicine, can solve the problems of incomplete extraction of active ingredients, unfavorable clinical application, poor oral absorption and utilization rate of monogastric animals, etc., to protect intestinal health, good anti-inflammatory effect, The effect of preventing livestock and poultry diarrhea

Active Publication Date: 2022-04-22
NANJING AGRICULTURAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is that the current traditional Chinese medicine used in the animal husbandry industry only adopts simple crushing or simple decoction, simple crushing, poor oral absorption and utilization rate of monogastric animals, simple decoction leads to incomplete extraction of active ingredients , unfavorable for clinical application and other problems, provide its preparation method of the above-mentioned traditional Chinese medicine compound feed additive

Method used

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  • A traditional Chinese medicine compound feed additive for replacing antibiotics and its preparation method and application
  • A traditional Chinese medicine compound feed additive for replacing antibiotics and its preparation method and application
  • A traditional Chinese medicine compound feed additive for replacing antibiotics and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Weigh 26 parts of Herba Vermiliae, 26 parts of Pteris vulgaris, 20 parts of Cactus, and 26 parts of Agrimony according to parts by weight, screen and remove impurities; crush the above-mentioned raw materials to 20-30 mesh.

[0042] Add 0.2% of the bacterium liquid prepared by Bacillus coagulans, lactic acid bacteria and saccharomyces in the material, after adding corn flour 3%, glucose 1%, (NH4) 2 SO 4 0.5%, calcium hydrogen phosphate 0.5%, then add water to adjust the moisture content of the material to 35%, and ferment at room temperature of 30°C for 8 days.

[0043] The dynamic countercurrent reflux extraction method is used for extraction, the extraction solvent is drinking water, the mass ratio of the solvent to the raw material is 10:1, the heating temperature is 80°C, and the extraction time is 2 hours; the above extract is concentrated to a density of 1.05g / cm 3 . The concentration method adopts a three-effect concentrator, and the vacuum degree and evaporat...

Embodiment 2

[0046] Weigh 30 parts of Herba Vermiliae, 30 parts of Pteris vulgaris, 20 parts of Cactus, and 30 parts of Agrimony according to parts by weight, screen and remove impurities; crush the above-mentioned raw materials to 20-30 mesh.

[0047] Add 0.2% of the gained bacterium liquid prepared by Bacillus coagulans, lactic acid bacteria and saccharomyces in the material, then add corn flour 3%, glucose 1%, (NH 4 ) 2 SO 4 0.5%, calcium hydrogen phosphate 0.5%, then add water to adjust the moisture content of the material to 35%, and ferment at room temperature of 30°C for 8 days.

[0048] The dynamic countercurrent reflux extraction method is used for extraction, the extraction solvent is drinking water, the mass ratio of the solvent to the raw material is 10:1, the heating temperature is 80°C, and the extraction time is 2 hours; the above extract is concentrated to a density of 1.05. The concentration method adopts a three-effect concentrator, and the vacuum degree and evaporatio...

Embodiment 3

[0058] Test: 1200 1-day-old white-feathered broiler chicks were randomly divided into 6 groups, 200 in each group, which were respectively three dosage groups of this product (prepared in Example 2), Pulsatilla Pulsatilla Powder group, antibiotic group and no addition of any drug group. Add 800, 500 and 300g / ton of feed to the product high, medium and low dose groups, add 2000g / ton of feed to the Pulsatilla powder group, add 300g / ton of bacitracin zinc to the feed for antibiotics, and add each drug to the feed continuously for 28 days. Observe the chicken's mental state, feed intake, and diarrhea. At the end of the experiment, 50 animals were randomly selected from each group, weighed, and the weight gain, feed-to-meat ratio and diarrhea rate were statistically calculated. The results are as follows (Table 2):

[0059] Table 2 broiler production indicators

[0060]

[0061]

[0062] Note: Diarrhea rate: 200 in each group (n=200), X2=30.890 among the 6 groups, the expec...

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Abstract

The invention discloses a traditional Chinese medicine compound feed additive which can replace antibiotics and its preparation method and application. The traditional Chinese medicine compound feed additive is made of traditional Chinese medicines which include the following components: Herba Vermilion, Pteris vulgaris, Cactus and Agrimony . The present invention screens the four traditional Chinese medicines that have good antibacterial and anti-inflammatory effects and are sensitive to Gram-negative bacteria (such as Escherichia coli), the four traditional Chinese medicines of Herba Vermilion, Pteris, Cactus and Agrimony; and study the improvement of the antibacterial effect of drug compatibility and clinical drug efficacy, to determine the compatibility ratio of Vernaceae, Plantain, Cactus, and Agrimony. The additive prepared by this formula can significantly improve the antibacterial effect, protect intestinal health, prevent livestock and poultry diarrhea, improve the digestion and absorption of feed nutrients and promote growth; at the same time, it can be applied to antibiotic-free breeding and animal husbandry to reduce the use of antibiotics , which has the characteristics of safety, no side effects, rapid effect, rapid disappearance of symptoms, and rapid effect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese veterinary medicine, and in particular relates to a traditional Chinese medicine compound feed additive for replacing antibiotics, a preparation method and application thereof. Background technique [0002] In the breeding industry, in order to control intestinal diseases of livestock and poultry and improve production efficiency, a large number of antibiotics are added to feed. The use of antibiotics in the animal husbandry industry has brought serious harm to the safety of animal products and human health. Therefore, looking for new antibiotic substitutes, improving animal immunity, increasing animal disease resistance, and reducing the harm of residual antibiotics to human health has become one of the urgent problems to be solved in my country's aquaculture industry. [0003] At present, traditional Chinese medicines that replace antibiotics with good antibacterial effects include ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23K10/30A23K10/12A23K20/163A23K20/26A23K50/75A23K50/60A23K50/30
CPCA23K10/30A23K10/12A23K20/163A23K20/26A23K50/75A23K50/60A23K50/30
Inventor 王德云武志勇刘振广朱少武
Owner NANJING AGRICULTURAL UNIVERSITY
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