Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

A kind of nifedipine sustained-release preparation and its preparation

A technology of nifedipine and sustained-release preparations, applied in the field of medicine, can solve the problems of unsatisfactory long-term stability, mixed quality and low bioavailability, and achieve the advantages of reducing the number of medications, taking them conveniently, and uniformly dispersing the dosage Effect

Active Publication Date: 2022-05-10
JINAN LIMIN PHARMA
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nifedipine tablets were first developed by Bayer in Germany, and later it was found that the bioavailability of ordinary nifedipine tablets was low and irregular in clinical application, and it was easy to cause heart and brain perfusion blood flow caused by too fast or too low blood pressure drop. If it is too low, it will induce angina pectoris, acute myocardial infarction and cerebral infarction. Later, Bayer Company of Germany developed nifedipine slow-release preparation instead of tablet for clinical treatment
[0003] At present, the number of generic oral preparations of nifedipine in my country is huge, and the quality is mixed. The existing nifedipine sustained-release preparations exist under different pH conditions, which cannot well protect the sustained-release properties of the drug from being affected. Long-term Unsatisfactory stability problem

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of nifedipine sustained-release preparation and its preparation
  • A kind of nifedipine sustained-release preparation and its preparation
  • A kind of nifedipine sustained-release preparation and its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1, a kind of nifedipine sustained-release preparation

[0036] The nifedipine sustained-release preparation comprises the following components and parts by mass thereof:

[0037] 15 parts of nifedipine, 15 parts of slow-release agent, 7 parts of binder, 50 parts of filler, 0.3 part of glidant, 3 parts of disintegrant, 0.2 part of magnesium stearate; Sodium, crospovidone and polyacrylic acid are composed of 10:6:3 by mass ratio; the binder is composed of polyvinyl alcohol and polyvinylpyrrolidone by 5:2 by mass ratio; the filler is composed of microcrystalline cellulose and The compressible starch is composed of a mass ratio of 5:2; the glidant is silicon dioxide; and the disintegrant is crospovidone.

[0038] The preparation method of described nifedipine sustained-release preparation, the steps are as follows:

[0039] S1 Grinding nifedipine to a particle size D90 of 10 μm to obtain nifedipine powder;

[0040] S2 respectively pulverize the sustained-relea...

Embodiment 2

[0045] Embodiment 2, a kind of nifedipine sustained-release preparation

[0046] The nifedipine sustained-release preparation comprises the following components and parts by mass thereof:

[0047] 20 parts of nifedipine, 25 parts of slow-release agent, 10 parts of binder, 70 parts of filler, 0.5 part of glidant, 5 parts of disintegrant, 0.6 part of magnesium stearate; Sodium, crospovidone and polyacrylic acid are composed of 15:3:1 by mass ratio; the binder is composed of polyvinyl alcohol and polyvinylpyrrolidone by 8:1 by mass ratio; the filler is composed of compressible starch, The mass ratio of mannitol and lactose is 10:5:3; the glidant is talc; the disintegrant is composed of sodium carboxymethyl starch and sodium lauryl starch in a mass ratio of 1:5.

[0048] The preparation method of described nifedipine sustained-release preparation, the steps are as follows:

[0049]S1 Grinding nifedipine to a particle size D90 of 50 μm to obtain nifedipine powder;

[0050] S2 re...

Embodiment 3

[0055] Embodiment 3, a kind of nifedipine sustained-release preparation

[0056] The nifedipine sustained-release preparation comprises the following components and parts by mass thereof:

[0057] 18 parts of nifedipine, 22 parts of sustained-release agent, 8 parts of binder, 62 parts of filler, 0.4 part of glidant, 4 parts of disintegrant, 0.4 part of magnesium stearate; Sodium, crospovidone and polyacrylic acid are composed of 12:5:2 by mass ratio; the binder is composed of polyvinyl alcohol and polyvinylpyrrolidone by 6:1 by mass ratio; the filler is composed of microcrystalline cellulose, Compressible starch and mannitol are formed in a mass ratio of 7:4:2; the glidant is silicon dioxide; the disintegrant is composed of carboxymethylcellulose calcium and sodium lauryl starch in a mass ratio of 9 :2 composition.

[0058] The preparation method of described nifedipine sustained-release preparation, the steps are as follows:

[0059] S1 Grinding nifedipine to a particle si...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention belongs to the technical field of medicine, and in particular relates to a nifedipine slow-release preparation and its preparation. The nifedipine sustained-release preparation provided by the invention comprises the following components and parts by mass: 15-20 parts of nifedipine, 15-25 parts of a sustained-release agent, 7-10 parts of a binder, and 50-70 parts of a filler , 0.3-0.5 part of glidant, 3-5 part of disintegrant, 0.2-0.6 part of magnesium stearate. The nifedipine slow-release preparation provided by the invention is convenient to take, can reduce the number of medications, has a long-lasting curative effect, is safe and reliable, and has good slow-release performance under different pH conditions, and can resist environmental changes in different positions of the gastrointestinal tract in the body. And has good long-term stability, stable product quality.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a nifedipine slow-release preparation and its preparation. Background technique [0002] The chemical name of nifedipine is 2,6-dimethyl-4(2-nitrophenyl-1,4-dihydro-3,5-pyridine-dicarboxylic acid dimethyl ester, and the molecular formula is C 17 h 18 N 2 o 6 . It is clinically used to prevent and treat various types of coronary heart disease and angina pectoris, and is also suitable for various types of hypertension, and has a good effect on intractable and severe hypertension. Biopharmaceuticals are classified as Class II, low solubility, high permeability drugs. Nifedipine tablets were first developed by Bayer in Germany, and later it was found that the bioavailability of ordinary nifedipine tablets was low and irregular in clinical application, and it was easy to cause heart and brain perfusion blood flow caused by too fast or too low blood pressure drop. If...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K47/32A61K47/38A61K47/36A61K31/4422A61P9/12
CPCA61K9/2054A61K9/2059A61K9/2027A61K9/205A61K9/2095A61K31/4422A61P9/12
Inventor 赵先亮颜东么亚娟
Owner JINAN LIMIN PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products