A kind of natural light-induced controlled-release drug and its preparation method and application

Abstract

The invention discloses a natural light-induced controlled-release drug. The natural light-induced controlled-release drug uses red blood cell membranes to entrap Endo and ICG; wherein, when the erythrocyte membrane is entrapped, the initial concentration of Endo is 5.0-25.0 mg / mL, and the initial concentration of ICG is 5.0-25.0 mg / mL. The initial concentration is 1.0-7.0mg / mL, and each milliliter of encapsulation solution contains 0.5mL of red blood cell membrane extracted from whole blood. The invention correlates the release amount of Endo with natural light, can effectively realize controlled release, and maintain good blood drug concentration.

Description

A kind of natural light-induced controlled-release drug and its preparation method and application technical field [0001] The present invention relates to a novel controlled-release drug of Endo (Endo). Background technique [0002] Indocyanine green (ICG) produces a large amount of singlet oxygen ( 1 [O2]) and its metabolites Hydrogen peroxide (H 2 O 2 ) increases, resulting in accumulation, which will destroy the phospholipid bilayer of the red blood cell membrane, which can make the red blood cell membrane pores open. open, the encapsulated drug is released from it, so as to complete the ICG-responsive drug release; when the light irradiation stops, the singlet oxygen, etc. The release amount is also reduced, the membrane pores are closed, and the drug release is stopped. The growth of solid tumors is closely related to the formation of tumor angiogenesis, and the rapid proliferation of tumor cells causes relative Hypoxia causes tumor tissue to continu...

AI Technical Summary

Problems solved by technology

[0003] The growth of solid tumors is closely related to the formation of tumor blood vessels. The relative hypoxia caused by the rapid proliferation of tumor cells makes the tumor tissue continue to produce pro-angiogenic factors, which destroys the original state of blood vessel balance, resulting in obvious tumor blood vessels. Heterogeneity, which worsens the tumor microenvironment, increases tumor malignancy and reduces therapeutic efficacy

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