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Biomarker for early diagnosis and/or recurrence monitoring of brain glioma and application of biomarker

A biomarker, glioma technology, applied in the field of biomarkers for early diagnosis and/or recurrence monitoring of glioma

Active Publication Date: 2020-09-15
SHANDONG UNIV QILU HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the diagnosis and liquid biopsy of CSF exosomes have been rarely reported so far

Method used

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  • Biomarker for early diagnosis and/or recurrence monitoring of brain glioma and application of biomarker
  • Biomarker for early diagnosis and/or recurrence monitoring of brain glioma and application of biomarker
  • Biomarker for early diagnosis and/or recurrence monitoring of brain glioma and application of biomarker

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Experimental program
Comparison scheme
Effect test

Embodiment

[0123] 91 cerebrospinal fluid exosome samples were selected, 88 of which were from the preoperative tumor-bearing state and postoperative non-tumor-bearing state control cerebrospinal fluid of 44 patients with glioma diagnosed and treated in Qilu Hospital (all signed informed consent, Histopathologically confirmed grade I-IV glioma patients with complete imaging data and medical records), and 3 cases of cerebrospinal fluid from normal control patients (obtained during hydrocephalus ventriculoperitoneal shunt surgery). Each cerebrospinal fluid sample was tested as follows:

[0124] 1. Extraction and identification of exosomes from cerebrospinal fluid

[0125] 1. All CSF samples were extracted by the gold standard density gradient ultracentrifugation method to extract exosomes.

[0126] 2. Take the exosomes obtained in step 1 and observe them with the gold standard transmission electron microscope for exosome identification. Exosomes were obtained from each CSF sample, see exe...

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Abstract

The invention provides a biomarker for early diagnosis and / or recurrence monitoring of brain glioma and an application of the biomarker, and belongs to the technical field of molecular diagnosis and molecular biology. Research of the invention discovers that the relative expression level of various miRNAs in the cerebrospinal fluid exosome is obviously related to glioma, the number of the miRNAs which are remarkably increased in the cerebrospinal fluid exosome of a glioma patient is 102, the number of the miRNAs which are remarkably decreased in the cerebrospinal fluid exosome of the glioma patient is 167, and the miRNAs and a marker spectrum which is composed of the miRNAs and contains 269 miRNAs have a high diagnosis value. Each of the 269 miRNAs can be independently used as a biomarkerof glioma, a marker spectrum set of the 269 miRNAs has a higher diagnostic value, and a rapid and accurate diagnostic mode is provided for clinic after combined application, so that diagnosis and recurrence detection of glioma are more convenient and easier to implement.

Description

technical field [0001] The invention belongs to the technical field of molecular diagnosis and molecular biology, and specifically relates to a biomarker for early diagnosis and / or recurrence monitoring of brain glioma and its application. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Human glioma is the most common malignant tumor of the central nervous system. Although its prognosis depends on many factors and diagnosis and treatment measures, generally speaking, the survival period of patients with grade III is 2-3 years, and the survival period of patients with grade IV is only one year. years or so. The clinical manifestations of malignant gliomas lack specificity...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/11
CPCC12Q1/6886G16B30/10C12Q2600/178C12Q2600/158C12Q2600/118
Inventor 薛皓李刚赵荣荣郭钦栋李柏延靳传娣李江冰薛付忠刘宏桑元华
Owner SHANDONG UNIV QILU HOSPITAL
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