Application of theanine in preparation of product for relieving alcoholic liver injury

A technology of alcoholic liver injury and theanine, which is applied in the fields of application, function of food ingredients, medical preparations containing active ingredients, etc., can solve problems such as unclear molecular mechanism, achieve the degree of relief of liver injury and relieve acute liver disease. Injury effect, effect of suppressing inflammatory response

Pending Publication Date: 2020-09-22
TEA RES INST GUANGDONG ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The above-mentioned patent documents do not specify the specific substances that play a key role in the medicines for the prevention and treatment of non-alcoholic liver disease or non-alcoholic fatty liver; and the molecular mechanisms of the substances that play a key role in the above-mentioned documents are not clear

Method used

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  • Application of theanine in preparation of product for relieving alcoholic liver injury
  • Application of theanine in preparation of product for relieving alcoholic liver injury
  • Application of theanine in preparation of product for relieving alcoholic liver injury

Examples

Experimental program
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Effect test

Embodiment 1

[0032] In the present invention, mice are subjected to one-time heavy drinking to make a mouse liver injury model, and the liver injury degree of the mice in the theanine group and the control group given the same dose of sterile water are compared, and the comparison of mouse liver case slices shows that , theanine significantly alleviated the degree of liver damage caused by one-time heavy drinking in mice, significantly reduced the levels of AST and ALT in the serum of mice after heavy drinking, and could increase the levels of superoxide dismutase SOD and gluten in the liver of mice Levels of glutathione peroxidase and decreased levels of malondialdehyde in the liver of hepatic-injured mice.

[0033] At the same time, the inventors studied the molecular mechanism of theanine in alleviating acute alcoholic liver injury in mice, and the results showed that theanine inhibited NF-κB-mediated inflammation by regulating the TNF-α / NF-κB signaling pathway Reaction, inhibit the exp...

Embodiment 2

[0044] (1) The alleviating effect of theanine on alcoholic liver injury in mice

[0045] Liver tissues of mice in each group were stained with hematoxylin and eosin, respectively. Such as figure 1 As shown, compared with the liver tissue of the normal control group (CG), the apoptosis of liver cells in the alcohol-treated model group (MG) was obvious, and the liver tissue was congested, swollen, vacuolated, and granule degenerated. Compared with the model group, the histology and structural morphology of the liver tissue sections of the L-theanine treatment group were improved, especially the liver tissue of the high-dose treatment group was close to the normal group.

[0046] (2) Effect of L-theanine on enzyme activity in mouse serum

[0047] The activity of ALT and AST and the ratio of the two are liver damage, an important marker index of liver inflammation. The inventor detects the activity of ALT and AST in mouse serum, and the results show that ( figure 2 ), compared...

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Abstract

The invention belongs to the field of application of active components in tea leaves, and specifically relates to application of theanine in preparation of a drug / food for relieving alcoholic liver injury. The invention emphatically protects the application of the theanine in the preparation of the drug / food for relieving the alcoholic liver injury, and specifically emphatically protects application of the theanine in the preparation of the drug / food for relieving a cute alcoholic liver injury. The invention relates to the theanine and mainly L-theanine. A large number of experiments prove that the theanine is capable of remarkably relieving the cute alcoholic liver injury caused due to heavy drinking once, and the experiments make clear that the theanine plays a reliving role through regulation and control of inflammatory factor signal channels related with NF-kB. The theanine, specifically the L-theanine provided by the invention has a remarkable effect in the relieving of the cute alcoholic liver injury. The theanine derives from a pure natural raw material of the tea leaves, is high in safety and environment-friendly and has no side effect to a human body.

Description

technical field [0001] The invention belongs to the application field of active ingredients in tea, and in particular relates to an application of theanine in the preparation of drugs / foods for alleviating alcoholic liver damage. Background technique [0002] The liver is the main site of alcohol metabolism. After drinking, ethanol is absorbed into the blood in the stomach and upper small intestine, and about 98% of ethanol is metabolized in the liver. degree of damage. Alcoholic liver injury is a common liver disease in clinical practice. It is a liver injury disease caused by long-term drinking, including alcoholic fatty liver, alcoholic hepatitis, alcoholic liver fibrosis, and alcoholic liver cirrhosis. Existence can also exist simultaneously. From histological analysis, alcohol damage to liver organs can be manifested as liver edema, liver fat, and liver fibrosis in different degrees; from the changes of biochemical indicators, there may be aspartate aminotransferase (...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K31/198A61K36/82A61P1/16A23L33/105A23L33/175
CPCA61K31/198A61K36/82A61P1/16A23L33/105A23L33/175A23V2002/00A23V2200/32
Inventor孙世利孙伶俐黎秋华陈若虹张文姬赖幸菲
OwnerTEA RES INST GUANGDONG ACAD OF AGRI SCI