Blood purification adsorbent and preparation method and application thereof

A blood purification and adsorbent technology, applied in chemical instruments and methods, blood circulation treatment, suction devices, etc., can solve the problem that adsorbent materials cannot take into account the biocompatible adsorption properties, chemical stability and suitable mechanical strength, etc. The effect of improving biocompatibility, improving biocompatibility, and improving adsorption capacity

Active Publication Date: 2020-09-22
苏州仝康医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Therefore, the technical problem to be solved in the present invention is to overcome the defects that existing adsorbent materials cannot take into account excellent biocompatibility, high adsorption performance, stable chemical stability and suitable mechanical strength.

Method used

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  • Blood purification adsorbent and preparation method and application thereof
  • Blood purification adsorbent and preparation method and application thereof
  • Blood purification adsorbent and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043]The blood purification adsorbent provided in this embodiment includes an inner core, a first outer modification layer and a second outer modification layer.

[0044] Porous structure with a core particle size of 0.02-2mm and a specific surface area of ​​800-1200m 2 / g, the sum of the pore volumes of mesopores (2-50nm) and macropores (>50nm) accounts for more than 90% of the total pore volume of the inner core, and the inner core of this structure has a strong adsorption capacity.

[0045] The above core uses a mixture of porous carbon-based materials and porous titanium-based materials. The porous carbon-based materials can be selected from activated carbon, graphene, graphene oxide, carbon nanotubes, etc., and the porous titanium-based materials can be selected from titanium dioxide nanotubes, porous titanium-molybdenum alloys, etc. .

[0046] In this embodiment, the porous carbon-based material adopts carbon nanotubes, the porous titanium-based material adopts titaniu...

Embodiment 2

[0060] The blood purification adsorbent provided in this embodiment is different from that in Embodiment 1 in that the blood purification adsorbent does not carry ligands, but only consists of an inner core, a first outer modification layer, and a second outer modification layer.

Embodiment 3

[0062] The blood purification adsorbent provided in this example is different from Example 1 in that the medical polymer with the structure shown in formula (I) in the second outer modification layer is replaced by conventional medical polymer polystyrene.

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Abstract

The invention belongs to the technical field of biological materials, and particularly relates to a blood purification adsorbent and a preparation method and application thereof. The blood purification adsorbent comprises an inner core with mesopores and macropores, a first outer modification layer distributed in the mesopores of the inner core, and a second outer modification layer distributed inthe macropores of the inner core, wherein the inner core comprises a porous carbon-based material and a porous titanium-based material, the first outer modification layer comprises polyvinyl alcohol,porous zinc oxide and porous tantalum oxide, the second outer modification layer comprises polyethylene glycol and medical macromolecules containing hydroxyl groups, and the ratio of the number of the hydroxyl groups to the number of carbon atoms in the medical macromolecules is not less than 1: 5. The blood purification adsorbent has good mechanical strength, adsorption performance and biocompatibility, and can adsorb pathogenic factors in blood or plasma.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a blood purification adsorbent and its preparation method and application. Background technique [0002] The occurrence and development of many diseases are caused by the accumulation of pathogenic factors in the body. Therefore, it is a clinical medicine that can specifically and effectively remove these pathogenic factors from the body by purifying the blood without causing damage to the body. problem that has been continuously explored in recent years. At present, an important method is blood purification and adsorption therapy, the principle of which is: after the patient's blood or plasma passes through an adsorption device equipped with a specific adsorbent, the pathogenic factors in the blood or plasma are bound to the adsorbent through a certain action and are eliminated. Be removed quickly to achieve the purpose of pathogenicity. [0003] Adsor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/30A61M1/16A61M1/36
CPCB01J20/262B01J20/261B01J20/06B01J20/20B01J20/0211B01J20/3078A61M1/1621A61M1/3679A61M1/3621Y02A50/30
Inventor 王为超陈荣胜虞金华邢雪奎
Owner 苏州仝康医疗科技有限公司
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