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Building method and application of PDX model for perineural invasion of slivary adenoid cystic carcinoma

A technology for adenoid cystic carcinoma and a construction method is applied in the field of construction of a salivary gland adenoid cystic carcinoma neural invasion PDX model, which can solve the problems of low success rate of PDX model construction and difficulty in establishing a SACC neural invasion PDX model.

Pending Publication Date: 2020-09-29
AIR FORCE MEDICAL UNIV
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Problems solved by technology

Since the sample size of SACC tumors is relatively small compared with common malignant tumors, and the success rate of PDX model construction is low, it is difficult to establish a PDX model of SACC nerve invasion.

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  • Building method and application of PDX model for perineural invasion of slivary adenoid cystic carcinoma
  • Building method and application of PDX model for perineural invasion of slivary adenoid cystic carcinoma
  • Building method and application of PDX model for perineural invasion of slivary adenoid cystic carcinoma

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[0030] In order to enable those skilled in the art to better understand the technical solutions in the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described The embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.

[0031] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the technical field of the invention. The terms used herein in the description of the present invention are for the purpose of describing specific embodiments only, and are not intended...

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Abstract

The invention relates to a building method and application of a PDX model for perineural invasion of a slivary adenoid cystic carcinoma. The building method comprises the steps of clinical in-vitro tumor sample treatment, building of the PDX model, and evaluation of the PDX model for perineural invasion. The purpose is to conduct comprehensive analysis and evaluation on the perineural invasion characteristic and mechanism of the SACC by building a standardized SACC perineural invasion PDX model library, and the building method and application of the PDX model for perineural invasion of the slivary adenoid cystic carcinoma have positive significance for finding and verification research of new intervention targets, common clinical tests and personalized treatment of the SACC.

Description

technical field [0001] The invention relates to the fields of biotechnology and medicine, in particular to a construction method and application of a salivary gland adenoid cystic carcinoma (SACC) nerve invasion PDX model. Background technique [0002] The PDX (patient-derived xenografts) model is a xenograft model that transplants fresh tumor tissue from a tumor patient into an SPF model mouse and grows in the environment provided by the mouse. This model stably retains the genetic characteristics, histological and phenotypic characteristics of the primary tumor, and the growth microenvironment of the tumor is closer to the actual situation. [0003] At present, there are CDX tumor models constructed by transplanting SACC tumor cell lines into nude mice, but there is no established PDX model of SACC neural invasion. There are many disadvantages in the current application of CDX models. On the one hand, because tumor cell lines are artificially purified and cultured for mul...

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Application Information

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IPC IPC(8): A01K67/027A61K49/00
CPCA01K67/0271A61K49/0008A01K2227/105A01K2267/03A01K2267/0393
Inventor 杨新杰魏建华王珺车蕾杨子桧李欢完颜超杰张峰瑞雷德林
Owner AIR FORCE MEDICAL UNIV
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