Device for judging sepsis infection conditions, and application thereof

A technology for sepsis and reactive protein, applied in the field of medical identification, can solve problems such as increasing the fatality rate, and achieve the effects of reducing misdiagnosis, good prediction performance, and improving the accuracy of diagnosis

Pending Publication Date: 2020-09-29
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Due to the lack of a method for quickly judging the condition of patients with sepsis, the patient's condi

Method used

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  • Device for judging sepsis infection conditions, and application thereof
  • Device for judging sepsis infection conditions, and application thereof
  • Device for judging sepsis infection conditions, and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] In this embodiment, an inflammation indicator, ie, mScore, is defined to detect infection more accurately.

[0060] (1) The changes of CRP, PCT and IL-6 concentrations in patients during infection are as follows: figure 1 generally, the higher the concentration of PCT, CRP and IL-6, the more severe the infection, and the combination of these three biomarkers can complement each other and improve the early diagnosis rate;

[0061] A new indicator, mScore, was defined based on the concentrations of these three biomarkers; mScore was calculated as follows:

[0062]

[0063] Among them, x, y, z: calculation coefficients of different biomarkers.

[0064] First, assume all coefficients are 1, and only change one of them, then calculate the AUC value of the resulting mScore. Such as figure 2 As shown, when x=1, y=1 and z=3, AUC has a maximum value compared with x=1, y=1 and z=1 or 2, and its AUC=0.812.

[0065] By optimizing the coefficients in front of different bioma...

Embodiment 2

[0076] This example is used to study the clinical value of mScore and mScorePlus.

[0077] In this example, 70 serum samples were used, including 36 samples of bacterial infection, 24 samples of viral infection and 10 samples of healthy human serum, all of which were from the 306th Hospital of the Chinese People's Liberation Army, to prove that based on various The clinical value of new indicators mScore and mScorePlus for biomarkers and CBC information.

[0078] (1) Clinical value of mScore

[0079] 1. mScore detects infection more effectively than individual biomarkers

[0080] Such as image 3 As shown, the P value of mScore was less than 0.0001, and the mScores of infected and uninfected were 74.37±48.69 and 3.04±0.54, respectively. Compared with a single indicator, mScore has no misjudgment in distinguishing infection from non-infection.

[0081] 2. mScore has higher accuracy in distinguishing bacterial and viral infections

[0082] Such as Figure 4 As shown, it ca...

Embodiment 3

[0093] This example is used to prove that the development trend of the biomarkers provided in the present invention conforms to the theoretical trend.

[0094] Before admission to the ICU, patient 1's duodenal malignancy had not received gastrointestinal feeding for a long time, so fungal infection and secondary infection needed to be prevented.

[0095] After admission to the ICU, about 150 mL of blood was drawn from the abdominal drainage tube, which would cause a drop in blood pressure and further lead to hemorrhagic shock. Point-of-care detection of inflammatory biomarkers with our dynamic multiplex POC immunoassay is very helpful in judging and controlling infection.

[0096] As shown in Figure 8(a) and Figure 8(b), according to the test results and clinical symptoms, the patient was diagnosed with mild abdominal infection. Meropenem for injection is used to treat infections. However, a marked increase in IL-6 the next day indicated an uncontrolled infection. The patie...

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Abstract

The invention provides a device for judging sepsis infection conditions, and application thereof. According to the device, the input variables of the device comprise concentrations of C reactive protein, procalcitonin and interleukin-6, and the device for judging sepsis infection conditions is constructed by taking the concentrations of the three markers as the input variables; and the output variable of the device is mScore or mScoreplus. According to the invention, mScore or mScoreplus is used as a new index of sepsis infection conditions to judge the infection degree of a patient, so that the accuracy is high, bacterial infection and virus infection can be distinguished, clinicians can be helped to diagnose accurately, and the device is an effective tool for detecting infection, distinguishing bacterial infection and virus infection and monitoring diseases.

Description

technical field [0001] The invention relates to the technical field of medical identification, and relates to a device for judging sepsis infection and its application. Background technique [0002] Septicemia refers to the acute systemic infection caused by various pathogenic bacteria invading the blood circulation, growing and multiplying in the blood, and producing toxins. If the bacteria that invade the bloodstream are cleared by the body's defense function, it is called bacteremia when there are no obvious symptoms of toxemia. Sepsis with multiple abscesses and a longer course is called sepsis (sepsis). [0003] Sepsis is a life-threatening disease caused by a dysregulated inflammatory immune response, a systemic infection caused by bacteria, bacteria, and viruses that leads to organ and immune system dysfunction. The incidence of sepsis is high, and the condition is dangerous, and the case fatality rate is high. To treat sepsis, the first step is to understand the p...

Claims

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Application Information

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IPC IPC(8): G01N33/68G01N33/74G01N33/543G16H50/30G01N15/10
CPCG01N33/6869G01N33/6893G01N33/74G01N33/54306G16H50/30G01N15/10G01N2333/4737G01N2333/5412G01N2333/585G01N2800/60G01N2800/7095G01N2015/1006Y02A90/10
Inventor 蒋兴宇牟磊
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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