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Adhesion member and microneedle patch

A technology of adhesive components and adhesives, applied in the direction of microneedles, needles, viscous dressings, etc., can solve the problem of not getting the effect of drug injection

Pending Publication Date: 2020-10-27
MEDRX CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the microneedle arrays that pierce the skin and stick by the method of injecting or pressing with the force of the spring, or the method of pressing with the strength of the hand, float from the skin due to the repulsive force of the skin, and cannot obtain sufficient medicine. Phenomena of injection effects become problematic

Method used

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  • Adhesion member and microneedle patch
  • Adhesion member and microneedle patch
  • Adhesion member and microneedle patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0127] [Example 1] Correlation between rigidity and floating of adhesive tape (patch)

[0128] (1) Calculation method of rigidity

[0129] (1-1) Test method

[0130] According to Japanese Industrial Standard (JIS K7171), passed Figure 13 The rigidity of the test piece (corresponding to the adhesive of the present invention or the support of the patch of the present invention. The same applies hereinafter) was obtained by the three-point bending test shown. The specific test method is as follows.

[0131] The test piece was placed on the two support tables, and the central part was subjected to a force with an indenter to bend it at a constant speed, and the force and deflection applied to the test piece were measured. An example of the load curve of the obtained test results is shown in Figure 14 .

[0132] Device: Small bench-top testing machine EZTest manufactured by Shimadzu Corporation

[0133] Test speed: 1mm / min

[0134] Distance between fulcrums: 12mm

[0135]...

Embodiment 2

[0179] [Example 2] Relationship between rigidity and stress applied to microneedles (evaluation of stress applied to microneedles)

[0180] (1) Production of human skin model

[0181] A silicon sheet (thickness 15 mm) with a hardness of 5 degrees was used as a human skin model. It should be noted that when the elasticity of the present model is compared with the elasticity of the skin, equivalent stress curves are drawn.

[0182] (2) Measuring method of stress applied to microneedles

[0183] This assay uses as Figure 16 The device shown was carried out. The lifting part of the device is equipped with a load cell, The plunger, the 10mm×10mm×H20mm spacer and the press-in fixture. Press into the fixture as Figure 16 Installed on the lifting part of the device like that, set it on the spacer A through hole through which the plunger connected to the load cell passes.

[0184] A 10 mm x 10 mm x 1 mm thick PET plate serving as a pseudo-microneedle array was placed on a h...

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Abstract

The present invention addresses the main problem, with regard to a patch that carries a microneedle array, of providing a novel patch that demonstrates superior fixing performance to skin. A patch inwhich a pressure-sensitive adhesive is mounted onto one surface of a support body and a microneedle array is carried on the surface on the adhesive layer side of an adhesive member characterized by having a stiffness of 1.3 MPa mm4, or said adhesive member can be cited, for example, as the present invention. This patch, etc. is useful as a medical product or the like because puncture performance of the microneedles is improved, the microneedle array can be fixed firmly to the skin, and a drug can be quantitatively administered without being wasted.

Description

technical field [0001] The present invention relates to an adhesive member. In addition, the present invention relates to a patch (microneedle patch) in which a microneedle array is carried on the adhesive member, an auxiliary tool for piercing the skin with the microneedles, and the like composed of the adhesive member. In particular, it relates to a microneedle patch excellent in fixability to the skin. Background technique [0002] Transdermal administration of pharmaceuticals using microneedle arrays is an area that has been actively studied in recent years. Furthermore, practical manufacturing methods of microneedle arrays have been studied by many companies (Patent Documents 1 and 2). In addition, for the method of attaching the microneedle array to the skin, methods using various devices have also been studied (Patent Documents 3 and 4), and as a mechanism for piercing the skin with the microneedles, ejection or pressing by spring force has been studied. method, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00A61F13/02
CPCA61M37/0015A61M2037/0023A61M2037/0061A61M2037/0046A61F13/0256
Inventor 小林胜则滨本英利
Owner MEDRX CO LTD
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