traditional Chinese medicine composition capable of resisting helicobacter pylori and application

An anti-Helicobacter pylori and composition technology, applied in the field of traditional Chinese medicine preparation, can solve the problems of limited curative effect, increase the impurity content of the extract, increase the dosage of Coptis chinensis, etc., and achieve the effects of improving curative effect, improving taste and eliminating side effects

Inactive Publication Date: 2020-11-10
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the curative effect of directly using them to kill HP is limited, and increasing the dosage of Coptis chinensis will increase the impurity content in the extract, which is likely to cause safety problems

Method used

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  • traditional Chinese medicine composition capable of resisting helicobacter pylori and application
  • traditional Chinese medicine composition capable of resisting helicobacter pylori and application
  • traditional Chinese medicine composition capable of resisting helicobacter pylori and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 A kind of preparation of the medicinal composition of anti-helicobacter pylori

[0023] 100Kg Cortex Phellodendri was soaked in 0.1% (V / V) sulfuric acid aqueous solution for 48 hours, then percolated and extracted; the extract was neutralized to pH=2 of the solution with lime aqueous solution, filtered, and the filtrate was concentrated under reduced pressure to 0.1g crude drug (Cortex Phellodendri) / mL; filter, and then add 5% (W / V) sodium chloride solution in the concentrated solution; stand still for 24 hours, filter; the precipitate is recrystallized once in 5 times of distilled water; obtain 3 kg of Cortex Phellodendri extract. The content of berberine in Phellodendron Phellodendri extract was analyzed by HPLC to be 98%.

[0024] 10kg Yuhuanglian was heated and refluxed with 70% ethanol to extract three times, the first time was 3 hours, the second time was 2 hours, and the third time was 1.5 hours, the extracts were combined, filtered, the ethyl alcoh...

Embodiment 2

[0026] Embodiment 2 A kind of preparation of the medicinal composition of anti-helicobacter pylori

[0027] 100Kg Cortex Phellodendri was soaked in 2% (V / V) sulfuric acid aqueous solution for 1 hour, then extracted by percolation; the extract was neutralized with lime to pH=5 of the solution, filtered, and the filtrate was concentrated under reduced pressure to 1 g crude drug (Cortex Phellodendri) / mL; Filter, then add 0.1% (W / V) sodium chloride; stand still for 24 hours, filter; the precipitate is recrystallized once in 5 times of distilled water; obtain 3.3 kg of Phellodendron Phellodendri extract, and the berberine content in the extract is 90% according to HPLC analysis.

[0028] 10kg Yuhuanglian was heated and refluxed with 40% ethanol to extract three times, the first time was 3 hours, the second time was 2 hours, the third time was 1.5 hours, the extracts were combined, filtered, the ethanol was recovered and concentrated into a thick paste to obtain Yuhuanglian extract ...

Embodiment 3

[0031] Embodiment 3 A kind of preparation of the medicinal composition of anti-helicobacter pylori

[0032] 100Kg Cortex Phellodendri was soaked in 0.5% (V / V) sulfuric acid aqueous solution for 12 hours, then extracted by percolation; the extract was neutralized with lime to pH=4 of the solution, filtered, and the filtrate was concentrated under reduced pressure to 0.4g crude drug (Cortex Phellodendri) / mL Filter, then add 2% (W / V) sodium chloride; Stand still for 12 hours, filter; Precipitate is recrystallized once in 5 times of distilled water; Obtain Cortex Phellodendri extract 3.1kg, berberine content 93% in the HPLC analysis extract .

[0033] 10kg Yuhuanglian was heated and refluxed with 50% ethanol to extract three times, the first time was 3 hours, the second time was 2 hours, the third time was 1.5 hours, the extracts were combined, filtered, the ethanol was recovered and concentrated into a thick paste to obtain Yuhuanglian extract 1.9kg.

[0034] 10kg of Akiras sin...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine preparation, and particularly relates to a traditional Chinese medicine composition capable of resisting helicobacter pylori and an application. The traditional Chinese medicine composition is improved on the basis of famous Zuojin pills and Xianglian pills and comprises a rhizoma coptidis extract, a fructus evodiae and coptis chinensis extract, and a cortex phellodendri extract, wherein the content of berberine is greater than 50%, the effect of resisting the helicobacter pylori is good, besides, through the combination with the fructus evodiae and costus roots, the side effects of the product are effectively eliminated, and the safety of the medicine is improved; the traditional Chinese medicine composition is used in combination with a clinical standard therapy (triple therapy) for treating HP, so that the curative effect can be further improved, and intestinal flora disorder caused by the triple therapy and toxic and side effects of the triple therapy can be repaired.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparation, and in particular relates to a traditional Chinese medicine composition for resisting Helicobacter pylori and its application. Background technique [0002] Coptis chinensis was first recorded in "Shen Nong's Materia Medica" and listed as top grade. Coptis chinensis is bitter in taste, cold in nature, and has the functions of purging fire, detoxifying, clearing away heat, and drying dampness. For dysphoria, confusion, upset and insomnia, hot and humid fullness, vomiting, abdominal pain and diarrhea, conjunctival congestion and swelling, sore tongue, eczema, burns, vomiting blood, epistaxis, etc. A large number of research results show that Coptidis Rhizome has a strong anti-Helicobacter pylori (HP) effect (Xu Yi et al. Study on the antibacterial effect of single and compound Chinese herbal medicines on Helicobacter pylori. Chinese Journal of Integrative Tradition...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61P31/04A61P1/00A61P35/00
CPCA61K36/285A61K36/718A61K36/756A61K2236/331A61K2236/333A61K2236/39A61K2236/53A61P1/00A61P31/04A61P35/00A61K2300/00
Inventor 叶小利李学刚
Owner SOUTHWEST UNIVERSITY
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