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Bioreactors

A bioreactor and microorganism technology, applied in the direction of bioreactor/fermenter combination, specific-purpose bioreactor/fermenter, biochemical instruments, etc., can solve the problem of small laboratory area, increased cost and pollution risk And other issues

Pending Publication Date: 2020-11-24
GLOBAL LIFE SCI SOLUTIONS USA LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Such cell bags have the disadvantage when an initial low volume of cells (which is referred to as the seed volume) is introduced into the bag
Furthermore, to achieve this seed volume, it is currently usually necessary to transfer a vial of cells suspended in approximately 1-2 ml of liquid to different vessels multiple times to allow the cells to proliferate sufficiently to provide a viable seed volume, determined by This increases cost and contamination risk
The footprint of the required equipment is too large for small laboratories

Method used

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Embodiment Construction

[0017] The present disclosure, together with its objects and advantages thereof, may be better understood by referring to the following description taken in conjunction with the accompanying drawings, in which like reference numerals designate like elements throughout.

[0018] The initial seed cell culture has a relatively low volume, eg, about 10 ml or less. Without being bound by theory, the proximity of cells in culture may be beneficial for growth. Thus, low volume initial seed cultures may benefit from being introduced into containers of relatively small volume during the initial growth phase and subsequently, successively (one or more times) transferred to (one or more) after growth. ) higher volume containers. However, such transfers result in increased cost, increased process complexity, and increased risk of contamination.

[0019] While containers such as bottles can be used instead of bags, conventional bottles also require multiple transfers of the seed volume i...

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Abstract

Disclosed are bioreactor flasks (10) including a volume extending between a first volume end and a second volume end for the cultivation of cells or other microorganisms, said volume having a horizontal cross section area (CSA) which increases in a direction from the first volume end to the second volume end. The flask optionally includes a housing including a cylindrical lower portion (14) and aninverted truncated conical upper portion (16) which provides said increasing CSA. Disclosed also are arrays of flasks (10), supported in a tray for collective agitation.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Application No. 62 / 662304, filed April 25, 2018, which is hereby incorporated by reference in its entirety. technical field [0003] The present disclosure relates to bioreactors, and in particular to bioreactor bottles for the cultivation of cells or other biological microorganisms. Background technique [0004] Traditionally, the bioprocessing industry has used stainless steel systems and piping in manufacturing processes for fermentation and cell culture. These devices are designed to be steam sterilized and reused. However, cleaning and sterilization are costly and labor intensive operations. Furthermore, the installation costs of these traditional systems with the necessary piping and utilities are often prohibitively high. Furthermore, these systems are typically designed for specific processes and cannot be easily reconfigured for new applications. In ...

Claims

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Application Information

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IPC IPC(8): C12M1/24C12M1/00
CPCC12M23/08C12M23/22C12M27/20
Inventor R·斯坦科夫斯基
Owner GLOBAL LIFE SCI SOLUTIONS USA LLC
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