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A kind of preparation method of surface coating modified vascular stent

A vascular stent and surface coating technology, applied in the field of medical devices, can solve problems such as fast degradation, loss of support capacity, difficulty in meeting service requirements, etc., to achieve the effect of slowing down the corrosion rate and prolonging the service life

Active Publication Date: 2021-11-19
乐普(深圳)国际发展中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many types of vascular stents, including polymers and metals. Magnesium alloy stents have the advantages of degradability and high support strength. Premature loss of supporting capacity in the body makes it difficult to meet service requirements
Most of the magnesium alloy stents in the prior art are coated with a single anti-corrosion layer on the surface of the stent. The bonding strength between the anti-corrosion layer and the stent is low, and it is easy to fall off during use, which cannot protect the magnesium alloy stent well.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: a kind of preparation method of the vascular stent of surface coating modification, comprises the following steps:

[0025] (a) The model of the vascular stent is prepared by 3D printing equipment, the model is placed in a container, gypsum is added to the container, after the gypsum is formed, the model is removed to form a gypsum mold with a cavity, and molten stent is poured into the cavity Magnesium alloy, cooled and formed to obtain the bracket matrix;

[0026] (b) In deionized water, use sandpaper to polish the surface of the stent matrix prepared in the above step (a) until it is bright, then rinse it with absolute ethanol for 2-3 times, and then place the stent matrix in a weak alkaline solution for ultrasonic cleaning 20min; after immersing the stent base completely in the corrosion solution, soak for 5min, and ultrasonically wash with absolute ethanol for 10min;

[0027] (c) placing the stent matrix after the above step (b) in an aqueous solutio...

Embodiment 2

[0033] Embodiment 2: a kind of preparation method of the vascular stent of surface coating modification, comprises the following steps:

[0034] (a) The model of the vascular stent is prepared by 3D printing equipment, the model is placed in a container, gypsum is added to the container, after the gypsum is formed, the model is removed to form a gypsum mold with a cavity, and molten stent is poured into the cavity Magnesium alloy, cooled and formed to obtain the bracket matrix;

[0035] (b) In deionized water, use sandpaper to polish the surface of the stent matrix prepared in the above step (a) until it is bright, then rinse it with absolute ethanol for 2-3 times, and then place the stent matrix in a weak alkaline solution for ultrasonic cleaning 15 minutes; after immersing the stent base completely in the corrosion solution, soak for 3 minutes, and ultrasonically wash with absolute ethanol for 20 minutes;

[0036] (c) placing the stent matrix after the above step (b) in an ...

Embodiment 3

[0042] Embodiment 3: a kind of preparation method of the vascular stent of surface coating modification, comprises the following steps:

[0043] (a) The model of the vascular stent is prepared by 3D printing equipment, the model is placed in a container, gypsum is added to the container, after the gypsum is formed, the model is removed to form a gypsum mold with a cavity, and molten stent is poured into the cavity Magnesium alloy, cooled and formed to obtain the bracket matrix;

[0044] (b) In deionized water, use sandpaper to polish the surface of the stent matrix prepared in the above step (a) until it is bright, then rinse it with absolute ethanol for 2-3 times, and then place the stent matrix in a weak alkaline solution for ultrasonic cleaning 15 minutes; after immersing the stent base completely in the corrosion solution, soak for 3 minutes, and ultrasonically wash with absolute ethanol for 20 minutes;

[0045] (c) placing the stent matrix after the above step (b) in an ...

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Abstract

The invention discloses a method for preparing a surface coating modified vascular stent, which comprises the following steps: preparing a stent matrix; completely immersing the stent matrix in a corrosion solution for 2-5 minutes; placing the stent matrix in absolute ethanol and In the aqueous solution of magnesium chloride, a magnesium oxide base layer is formed on the surface; the dopamine layer is deposited by immersing the stent substrate in the dopamine hydrochloride solution; a polymer layer is prepared on the stent substrate; the stent substrate is placed in the nickel solution, heated to 70-80°C, Soak for 50-60min; then place the stent matrix in stearic acid ethanol solution, soak for 30-40min to prepare a hydrophobic layer; prepare a drug-loaded layer by ultrasonic spraying process, and dry naturally to obtain a vascular stent.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a method for preparing a surface coating-modified vascular stent. Background technique [0002] Vascular stent is a tubular device used to support narrowed and occluded blood vessels in the human body, reduce elastic recoil and reshaping of blood vessels, and maintain smooth blood flow in the lumen. There are many types of vascular stents, including polymers and metals. Magnesium alloy stents have the advantages of degradability and high support strength. The premature loss of supporting capacity in the body makes it difficult to meet the service requirements. Most of the magnesium alloy stents in the prior art are coated with a single anti-corrosion layer on the surface of the stent. The bonding strength between the anti-corrosion layer and the stent is low, and it is easy to fall off during use, which cannot protect the magnesium alloy stent well. Content...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/10A61L31/08A61L31/02A61L31/14A61L31/16A61F2/06
CPCA61F2/06A61F2240/002A61F2240/004A61L31/022A61L31/08A61L31/088A61L31/10A61L31/14A61L31/16A61L2300/236A61L2300/42A61L2300/606A61L2400/18A61L2420/02A61L2420/04A61L2420/06A61L2420/08C08L67/04C08L5/10
Inventor 陈果戴燕王友凯
Owner 乐普(深圳)国际发展中心有限公司