Glucose biosensor, preparation method and application based on pdms microfluidic channel
A biosensor and microfluidic channel technology, applied in chemical instruments and methods, laboratory containers, instruments, etc., can solve the problems of expensive microwave sensors, complex design of peripheral matching circuits and display modules of vector network analyzers, etc. To achieve the effect of being conducive to commercial promotion and application, reducing processing costs and saving costs
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Embodiment 1
[0031] A glucose biosensor based on a PDMS microfluidic channel, when designing, use Advanced Design System 2015 software on a computer to design and simulate a compact glucose biosensor based on a PDMS microfluidic channel; its specific structure is as follows: figure 1 As shown, a glass substrate as a carrier is included, and a metal structure is arranged on the glass substrate; the metal structure is a metal layer gradually superimposed on the glass substrate, which in turn includes the first seed metal layer sputtered and grown on the glass substrate, The thickness is 20-50nm, and the material is titanium or chromium; the second seed metal layer grown on the first seed metal layer by sputtering has a thickness of 30-100nm; the second seed metal layer is made of gold to improve the semiconductor substrate. Adhesion to subsequent device metal layers.
[0032] A patterned photoresist layer is formed on the second seed metal layer, and the window of the patterned photoresist l...
Embodiment 2
[0036] A method for preparing a glucose biosensor, comprising the steps of:
[0037] S1: Cleaning the glass substrate; cleaning the glass substrate includes the following steps: cleaning with isopropylamine solution once, and then cleaning with deionized aqueous solution for the second time; cleaning the glass substrate with SPM solution, cleaning with isopropylamine solution again, and then cleaning with deionized water aqueous solution for secondary cleaning; the SPM solution contains H 2 SO 4 、H 2 o 2 、H 2 O.
[0038] S2: Build a metal structure on a glass substrate; the method for building a metal structure includes the following steps: growing a layer of titanium or chromium with a thickness of 20-50 nm as the first seed metal layer by a sputtering method, and then growing a layer of titanium or chromium by a sputtering method A layer of gold with a thickness of 30-100nm is used as the second seed metal layer; a patterned photoresist layer is formed on the second see...
Embodiment 3
[0048] When using the sensors in Examples 1 and 2, it can be applied in the field of biosensors and microwave resonators. When applied in the field of biosensors, it can be completed by injecting the glucose solution to be measured in the PDMS microfluidic channel. Detection of glucose solution concentration.
[0049] The detection principle of the glucose biosensor based on the PDMS microfluidic channel is: the resistance temperature sensor with a meandering line structure is placed in the front end of the capacitive biosensor, and the temperature change of the glucose solution to be tested is measured at a working frequency of 1MHz. The temperature sensing response is characterized by the relationship between resistance value and temperature. For the measurement of the temperature of the glucose solution to be tested, it is beneficial to calibrate the influence of the ambient temperature on the dielectric constant of the glucose solution itself, and increase the accuracy of ...
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