Single-cell mass spectrometry system and method
A mass spectrometry and single-cell technology, applied in the field of cell analysis, can solve problems such as inaccurate positioning, cross-contamination, and cumbersome steps, and achieve the effects of improving judgment accuracy, improving efficiency and precision, and high analysis accuracy
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Example Embodiment
[0036] Example 1:
[0037] figure 1 A structural diagram of a single-cell mass spectrometry system according to Example 1 of the present invention is shown schematically, such as figure 1 As shown, the single cell mass spectrometry system includes:
[0038] The carrier 11, and the plurality of cells are adapted to be carried by the carrier and separated from each other;
[0039] The extraction unit 21, the extracting unit comprises an extraction pipe and a discharge electrode, and an extract in the conduit forms a spray exiting from the bottom of the pipe under the action of the discharge electrode;
[0040] Moving units such as a three-dimensional mobile platform, the pipe or carrier is driven under the moving unit such that the bottom end of the extraction liquid conduit is selectively moved to the upper side of any cell;
[0041] The isolation unit 41, such as a spacer cover, the isolation unit for forming a space that isolates any cell from other cells; the bottom end of the ...
Example Embodiment
[0066] Example 2:
[0067] Application examples of single cell mass spectrometry system and method according to Embodiment 1 of the present invention.
[0068] In this application example, the carrier is a matrix structure, having a rectangular groove that is array-distributed, each groove adapted to accommodate a single cell;
[0069] The isolation unit is separated from the isolation cover, from the upper and lower isolation hoods, the inside of the spacer is large, the bottom end of the spacer is a rectangular shape that matches the groove of the carrier; the isolation cover is over the carrier On the groove, a space that is isolated from other grooves is formed, and there is only one rectangular groove in the space, i.e., only one cell in the space;
[0070] The mobile unit uses a three-dimensional mobile platform for driving the carrier three-dimensional movement, such as moving movement in the horizontal plane, so that the isolation cover (relatively) moves to any of the rec...
Example Embodiment
[0086] Example 3:
[0087] According to an application example of a single cell mass spectrometry system and method according to Embodiment 1 of the present invention, it is:
[0088] The carrier fixation, the mass spectrometer is fixed, the isolation cover, the extraction unit and the collecting unit are relatively fixed, and the three-dimensional moving spacer is driven to the same moving unit, thereby deduction on a rectangular groove having a cell at the designated position; While forming a spaced space on the rectangular groove, the bottom end of the extract is in the upper side of a single cell in the space.
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