COMPOSITIONS AND METHODS OF USE OF beta-HYDROXY-beta-METHYLBUTYRATE (HMB) ASSOSIATED WITH INTERMITTENT FASTING

A methylbutyric acid, intermittent technology, applied in the direction of drug combination, food science, function of food ingredients, etc., can solve problems such as lower resting metabolic rate

Pending Publication Date: 2020-12-18
TEXAS TECH UNIV OFFICE OF RES COMMLIZATION +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Additionally, intermittent fasting and HMB increased resting metabolic rate, whereas control diet and intermittent fasting groups decreased resting metabolic rate

Method used

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  • COMPOSITIONS AND METHODS OF USE OF beta-HYDROXY-beta-METHYLBUTYRATE (HMB) ASSOSIATED WITH INTERMITTENT FASTING
  • COMPOSITIONS AND METHODS OF USE OF beta-HYDROXY-beta-METHYLBUTYRATE (HMB) ASSOSIATED WITH INTERMITTENT FASTING
  • COMPOSITIONS AND METHODS OF USE OF beta-HYDROXY-beta-METHYLBUTYRATE (HMB) ASSOSIATED WITH INTERMITTENT FASTING

Examples

Experimental program
Comparison scheme
Effect test

experiment Embodiment 1

[0056] design

[0057] The study used a randomized, placebo-controlled, factor-reducing design and was double-blind with regard to supplementation in the TRF group. Active women were randomly assigned to control diet (CD), TRF, or TRF plus 3g / d HMB (TRF HMB ). The TRF group consumed all calories within ~8h / d. All groups completed 8 weeks of supervised RT and consumed supplemental whey protein. Body composition, muscle performance, dietary intake, physical activity, and physiological variables were assessed. Data were analyzed before unblinding using mixed models with per-protocol (PP) and intention-to-treat (ITT) frameworks.

[0058] Participants and methods

[0059] overview

[0060] The study used a randomized, placebo-controlled, reducing factorial design. Experiments were double-blind with respect to HMB and placebo supplementation and, where possible, single-blind with respect to the assigned dietary program. The following primary outcome measures were specified...

experiment Embodiment 2

[0137] The amount of fat loss that occurs with β-hydroxy-β-methylbutyrate (HMB) supplementation can be increased when combined with intermittent fasting. In this example, it was demonstrated that HMB supplementation with intermittent fasting resulted in greater fat loss than HMB supplementation alone.

[0138] In Example 1, active females (n=7, 22±3.3y, 63.7±7.0 kg) were randomized to time-restricted feeding plus 3 g / d calcium HMB (TRFHMB). The TRFHMB group consumed all calories within ~8h / d. The TRFHMB group completed 8 weeks of supervised resistance training. At baseline, and at 4 and 8 weeks, a modified 4-component (4C) model was used 1,2 Body composition was assessed and the models were generated from dual energy X-ray absorptiometry (DXA) and bioimpedance spectroscopy (BIS) data. DXA scans were performed on a LunarProdigy scanner (General Electric, Boston, MA, USA) with enCORE software (v.16.2).

[0139] In an earlier study described by Panton et al. (54), trained and...

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Abstract

The present invention provides a composition comprising HMB and methods of using HMB to mitigate loss of lean body mass, increase fat free mass, improve muscular performance, increase body fat loss and decrease body fat percentage in individuals undergoing intermittent.

Description

[0001] Background of the invention [0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 613,952, filed January 5, 2018, and is incorporated herein by reference. technical field [0003] The present invention relates to compositions comprising β-hydroxy-β-methylbutyrate (HMB) and the use of said compositions in combination with intermittent fasting (IF) to alleviate loss of lean body mass, increase fat-free mass, improve Methods for muscle performance, increased body fat loss, and decreased body fat percentage. Background technique [0004] The increasing prevalence of obesity is a major health crisis. Approximately 50% of the US adult population is projected to be obese by 2030, with major consequences being an increase in type 2 diabetes (T2D), cardiovascular disease (CVD), hypertension, and many cancers. Effective long-term treatments are lacking and, as a result, alternative approaches for managing obesity are being investigated with ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/19A61P3/04
CPCA61P21/00A61P3/04A61K31/19A61K9/0019A61K9/0053A23V2002/00A23L33/10A23V2200/332A61P3/02A23V2200/316A23V2250/30
Inventor G·廷斯利J·拉特马克L·皮奇福德
Owner TEXAS TECH UNIV OFFICE OF RES COMMLIZATION
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