PEGylated heparin nano-micelle for loading carboxylic acid anti-tumor drug and preparation method of PEGylated heparin nano-micelle
An anti-tumor drug and nanomicelle technology, applied in the field of medicine, can solve the problems of difficult to act on the target site, unable to pass, poor biocompatibility of the carrier, etc., to prevent the degradation of external factors or unnecessary metabolism. Inactivation, large safe dose, reducing the effect of total toxic and side effects
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Embodiment 1
[0043] Pemetrexed disodium is loaded on the PEGylated heparin molecule, the structure is as follows:
[0044] ,
[0045] in,
[0046]
[0047] PEG-HP stands for PEGylated heparin polymer with the structure:
[0048] ,
[0049] can also be
[0050]
[0051] Wherein, the acyl group is connected to the hydroxyl group at the end of polyethylene glycol through an ester bond.
Embodiment 2
[0053] Loading bendamustine on PEGylated heparin molecules, the structure is as follows:
[0054]
[0055] PEG-HP stands for PEGylated heparin polymer with the structure:
[0056] ,
[0057] can also be
[0058]
[0059] Wherein, the acyl group is connected to the hydroxyl group at the end of polyethylene glycol through an ester bond.
Embodiment 3
[0061] Load raltitrexed on the PEGylated heparin molecule, the structure is as follows:
[0062]
[0063] PEG-HP stands for PEGylated heparin polymer with the structure:
[0064] ,
[0065] can also be
[0066]
[0067] Wherein, the acyl group is connected to the hydroxyl group at the end of polyethylene glycol through an ester bond.
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