Antibacterial hydrogel with bactericidal, low bacterial adhesion and bacterial release, preparation method and application thereof

A technology of bacterial adhesion and hydrogel, applied in bandages, medical science, etc., can solve the problems of unsuitable for industrial mass production and application, poor biocompatibility of hydrogel, poor biocompatibility, etc., and achieve excellent biophase Compatibility, high biocompatibility, low cost effect

Active Publication Date: 2021-06-22
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The patent application literature with the publication number CN107868260A discloses a preparation method of a new type of hydrogel with low bacterial adhesion, sterilization and regeneration, including UV polymerization reaction, esterification reaction, ATRP reaction and silver loading reaction. The hydrogel has poor biocompatibility and is not suitable for application as a wound dressing, and the preparation method is very cumbersome and is not suitable for industrialized large-scale production applications
[0005] The current antibacterial hydrogel still has problems such as complicated preparation process, poor biocompatibility, and single function. Therefore, a multifunctional antibacterial hydrogel with simple preparation method and good biocompatibility for wound dressings has been developed in The field of biomedicine has broad application prospects and potential value

Method used

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  • Antibacterial hydrogel with bactericidal, low bacterial adhesion and bacterial release, preparation method and application thereof
  • Antibacterial hydrogel with bactericidal, low bacterial adhesion and bacterial release, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Take 1.18g DVBAPS and 0.08g GMA and place them in a 25ml round bottom flask containing 5ml each of water and trifluoroethanol. After stirring for 30min under nitrogen, add 0.02g of azobisisobutyronitrile and continue the process under nitrogen. Stirring for 20min under the condition of 60°C, reacting for 6h, then lyophilizing to collect poly(DVBAPS-co-GMA) copolymer solid samples after dialysis for a period of time;

[0034] (2) Put 0.25g poly(DVBAPS-co-GMA) and 0.5g PEGDGE in a container, add 1ml brine, the concentration of brine is 0.5M, stir well at 60°C, add 0.5g lysine after dissolution and continue Stir to dissolve, transfer the solution to a spare mold, and place it in an air blast oven at 80° C. for 2 hours to obtain an antibacterial hydrogel with a thickness of 1 mm.

[0035] figure 2 It is the surface fluorescence micrograph of the antibacterial hydrogel obtained in Example 1 for sterilization, low bacterial adhesion, and bacterial release, and the relat...

Embodiment 2

[0038] (1) Take 1.18g DVBAPS and 0.08g GMA and place them in a 25ml round bottom flask containing 5ml each of water and trifluoroethanol. After stirring for 30min under nitrogen, add 0.02g of azobisisobutyronitrile and continue the process under nitrogen. Stirring for 20min under the condition of 60°C, reacting for 6h, then lyophilizing to collect poly(DVBAPS-co-GMA) copolymer solid samples after dialysis for a period of time;

[0039] (2) Take 1.25g HEAA and 0.08g GMA and place them in a 25ml round bottom flask containing 5ml each of water and dimethyl sulfoxide. After stirring for 30min under nitrogen gas, add 0.02g potassium persulfate and continue to nitrogen gas Stirring for 20 minutes under the condition of 60°C, reacting for 6 hours, then dialysis for a period of time and freeze-drying to collect poly(HEAA-co-GMA) copolymer solid samples;

[0040] (3) Put 0.25g poly(DVBAPS-co-GMA) and 0.5g poly(HEAA-co-GMA) into a container, add 1ml deionized water, stir well at 60°C, a...

Embodiment 3

[0042](1) Get 0.47g NIPAM and 0.08g GMA and place them in a 25ml round-bottomed flask containing 5ml of water and trifluoroethanol. After stirring for 30min under the condition of nitrogen, add 0.02g of azobisisobutyronitrile and continue the process under nitrogen. Stirring for 20 minutes under the condition of 60°C, reacting for 6 hours, then lyophilizing to collect poly(NIPAM-co-GMA) copolymer solid samples after dialysis for a period of time;

[0043] (2) Take 1.25g of HEAA and 0.08g of GMA and place them in a 25ml round bottom flask containing 5ml of water and 5ml of dimethyl sulfoxide, stir for 30min under nitrogen, add 0.02g of azobisisobutylcyanide Continue to stir for 20 min under nitrogen, react at 60°C for 6 h, then freeze-dry to collect poly(HEAA-co-GMA) copolymer solid samples after dialysis for a period of time;

[0044] (3) Take 0.25g poly(DVBAPS-co-GMA) and 0.5g poly(HEAA-co-GMA) in a container, add 0.5ml deionized water and 0.5ml dimethyl sulfoxide, fully Sti...

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Abstract

The invention belongs to the field of hydrogels, and specifically discloses a preparation method of antibacterial hydrogels with sterilizing, low bacterial adhesion and bacterial release, including: 1) mixing responsive monomers with epoxy monomers to carry out free radical Copolymerization reaction to obtain epoxy-containing responsive polymers; 2) Mix epoxy-containing responsive polymers with epoxy-containing hydrophilic polymers and dissolve them in a solvent, add amino-containing bactericides to carry out epoxy-opening ring reaction. The invention also discloses the antibacterial hydrogel prepared by the above preparation method, which has the advantages of sterilization, low bacterial adhesion and bacterial release and its application as a wound dressing. The preparation process of the method of the invention is simple and efficient, and the obtained hydrogel has comprehensive functions and good biocompatibility, has broad research prospects in the fields of biomedicine and tissue engineering, and provides a new idea for the preparation of functional materials.

Description

technical field [0001] The invention belongs to the field of hydrogels, and in particular relates to an antibacterial hydrogel with sterilization, low bacterial adhesion and bacterial release, a preparation method and application thereof. Background technique [0002] Bacteria widely exist in nature, and the attachment and reproduction of some bacteria seriously threaten human health and normal life. According to statistics, about 60-70% of nosocomial infections are related to biological material-related infections. It is of great significance to human health to resist the attachment and proliferation of bacteria by constructing antibacterial surfaces. At present, antibacterial methods are mainly divided into three categories, namely, sterilization, anti-bacterial adhesion and bacterial release, and are gradually developing into multi-functional antibacterial methods. [0003] Hydrogels have broad application prospects in the field of wound dressings due to their inherent ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G81/02C08F212/14C08F220/32C08F220/58C08F220/54C08F220/06A61L26/00
CPCA61L26/0019A61L26/0061A61L26/0066A61L26/008A61L2300/214A61L2300/232A61L2300/404C08F212/14C08F220/06C08F220/54C08F220/58C08G81/021C08G81/025C08L87/005
Inventor 杨晋涛吴家慧袁静锋钟明强陈枫范萍
Owner ZHEJIANG UNIV OF TECH
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