Oral pharmaceutical composition of somatostatin or analogues thereof

Abstract

The invention belongs to the field of biological medicines, and particularly relates to an oral pharmaceutical composition of somatostatin or analogues thereof. The pharmaceutical composition is prepared from somatostatin and/or the somatostatin analogues and a pharmaceutical composition for promoting small intestine absorption, wherein the pharmaceutical composition for promoting small intestineabsorption is prepared from lauryl sodium sulfate, carbomer, chitosan and sodium citrate. A composite auxiliary material is prepared from the pharmaceutical composition for promoting small intestine absorption, and after the auxiliary material is combined with somatostatin and/or the somatostatin analogues, the absorption of the effective component in small intestines can be improved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to an oral pharmaceutical composition of somatostatin or its analogs. Background technique [0002] Somatostatin (somatostatin, growth hormone release-inlease-inhibiting hormone, GHRIH, or somatostatin) is a fourteen peptide that is cleaved from a macromolecular peptide of 116 amino acids, and its structure is cyclic. There is a disulfide bond between the 3-position and the 14-position cysteine; somatostatin is a neurohormone with a wide range of effects, and its main function is to inhibit the basal secretion of pituitary growth hormone (GH) and also inhibit the glandular The pituitary gland responds to GH secretion caused by various stimuli, including exercise, meals, stress, hypoglycemia, etc. In addition, somatostatin can also inhibit the secretion of LH, FSH, TSH, PRL and ACTH. Somatostatin plays a role by reducing intracellular cAMP and Ca2 after binding to t...

AI Technical Summary

Problems solved by technology

[0003] Neither somatostatin and its analogs can be taken orally, which leads to poor patient compliance. T

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