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Scoring method for quantifying TIME infiltration mode

A pattern and gene technology, applied in the field of quantifying the scoring of the TIME infiltration pattern, can solve the problems of inability to obtain consistent results and small sample size.

Pending Publication Date: 2021-01-01
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a scoring method for quantifying TIME infiltration patterns, so as to solve the problems that the sample size is too small and consistent results cannot be obtained in the above-mentioned background technology

Method used

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Embodiment Construction

[0022] Through the above specific implementation manners, the technical solutions in the embodiments of the present invention are clearly and completely described. Apparently, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0023] According to the above embodiments, the present invention provides a technical solution: 1. A scoring method for quantifying TIME infiltration patterns, characterized in that: the present invention includes the following steps: (1) Data collection and processing: the data of the modeling set comes from Hepatocellular carcinoma microarray data set of GEO database;

[0024] (2) Assessment of immune cell infiltration: 1) Use a set of genes rather than a single gene to repre...

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Abstract

The invention discloses a scoring method for quantifying a TIME infiltration mode; the score for quantifying the TIME infiltration mode is called as a TIME index (TI), the TI is an excellent prognosisprediction index in hepatocellular carcinoma and pancreas carcinoma, and the performance of the TI in predicting immunotherapy response is superior to that of other 11 biomarkers. The results can strengthen the understanding of the immune microenvironment and guide more effective personalized treatment, and the TIME1 is characterized by immune cell depletion and cell proliferation and correspondsto immunodeficiency types; tIME2 is characterized by being in an immunosuppression state, and a potential immune escape mechanism of each phenotype is emphasized corresponding to immunosuppression: TIME1 is characterized by tumor infiltration leukocyte deficiency and tumor antigen presentation capability defects; the TIME2 has more immunosuppressive cells; the TIME3 is rich in immunosuppressive cytokines and immune checkpoint molecules.

Description

technical field [0001] The present invention relates to a scoring method for quantifying TIME infiltration patterns. Background technique [0002] Hepatocellular carcinoma (hepatocellular carcinoma) is the major histological type of primary liver cancer with high morbidity and mortality, although there are various treatment modalities for hepatocellular carcinoma, including surgical resection, chemotherapy, radiofrequency ablation, liver transplantation etc., but the recurrence rate and prognosis are still unsatisfactory. Recently, immunotherapy as a new treatment approach has made great progress in hepatocellular carcinoma, but so far, only a subset of patients benefited, and insufficient understanding of the tumor immune microenvironment (TIME) may be responsible for the disappointing results. The main reason for disappointment is that at the individual level, HCC has significant TIME heterogeneity, and a comprehensive understanding of this heterogeneity is crucial for cl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B20/30G16B50/00C12Q1/6886
CPCC12Q1/6886C12Q2600/158G16B20/30G16B50/00
Inventor 韩新巍刘灶渠焦德超张玉元时程程周学良
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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