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Oral drops for acute and chronic nasosinusitis and rhinitis of children and preparation method thereof

A technique of oral drops for chronic sinusitis, which is applied in the field of traditional Chinese medicine, can solve the problems of taking large doses of traditional Chinese medicine decoctions, achieve the effect of improving bitterness and astringency, relieving systemic symptoms, and good clinical significance

Inactive Publication Date: 2021-01-22
GUANGXI XIANGJU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional Chinese medicine has its unique advantages in treating rhinitis. Its biggest feature is that it has less side effects and can cure the disease more thoroughly. However, due to children’s fear of traditional Chinese medicine techniques such as acupuncture and massage, Chinese medicine decoctions are taken in large quantities and taste bitter. and other reasons, traditional Chinese medicine is difficult to be accepted by children, and it is difficult to persist in treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] S1. Take the following raw materials in parts by weight: 15 parts of Huaxiangshu infructome, 16 parts of Prunella vulgaris, 12 parts of wild chrysanthemum, 12 parts of Rhizoma Chuanxiong, 13 parts of Angelica dahurica, 13 parts of Magnolia Magnolia, 12 parts of Fangfeng, 12 parts of Astragalus, licorice 12 parts, a total of 11.7kg, mixed the 9 traditional Chinese medicines, added 5 times the amount of water to decoct twice, each time for 1 hour, combined the decoction, filtered, and concentrated the filtrate to a relative density of 1.15 at 60°C;

[0038] S2. Take the filtrate obtained in step S1, add a certain amount of ethanol to make the alcohol content to 60%, stir evenly, let stand and filter, recover ethanol, and concentrate the filtrate under reduced pressure to a relative density of 1.15 at 60°C ;

[0039] S3. Take 25 parts of honey, 0.2 parts of sodium benzoate, and 0.3 parts of sucralose according to the ratio of auxiliary materials, and add them to the filtra...

Embodiment 2

[0041]S1. Take the following raw materials in parts by weight: 15 parts of Huaxiangshu infructome, 15 parts of Prunella vulgaris, 10 parts of wild chrysanthemum, 10 parts of Rhizoma Chuanxiong, 10 parts of Angelica dahurica, 10 parts of Magnolia magnolia, 10 parts of Fangfeng, 10 parts of Astragalus, 10 parts of licorice 10kg in total, mix the 9 traditional Chinese medicines, add 8 times the amount of water to decoct twice, each time for 1 hour, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.15 at 60°C;

[0042] S2. Take the filtrate obtained in step S1, add a certain amount of ethanol to make the alcohol content to 60%, stir evenly, let stand and filter, recover ethanol, and concentrate the filtrate under reduced pressure to a relative density of 1.15 at 60°C ;

[0043] S3. Take 30 parts of honey, 0.2 parts of sodium benzoate, and 0.3 parts of sucralose according to the ratio of auxiliary materials, and add them to the filtrate obtained...

Embodiment 3

[0045] S1. Take the following raw materials in parts by weight: 20 parts of Huaxiangshu infructome, 20 parts of Prunella vulgaris, 15 parts of wild chrysanthemum, 15 parts of Rhizoma Chuanxiong, 15 parts of Angelica dahurica, 15 parts of Magnolia officinalis, 15 parts of Fangfeng, 15 parts of Astragalus, 15 parts of licorice 11.6kg in total, mix the 9 traditional Chinese medicines, add 10 times the amount of water to decoct twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.20 at 60°C;

[0046] S2. Take the filtrate obtained in step S1, add a certain amount of ethanol to make the alcohol content to 60%, stir evenly, let stand and filter, recover ethanol, and concentrate the filtrate under reduced pressure to a relative density of 1.20 at 60°C ;

[0047] S3. Take 32 parts of honey, 0.2 parts of sodium benzoate, and 0.3 parts of sucralose according to the proportion of auxiliary materials, and add them to the filt...

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Abstract

The invention discloses oral drops for acute and chronic nasosinusitis and rhinitis of children. The oral drops are prepared by adding honey, sodium benzoate, citric acid, sucralose and other auxiliary materials into nine crude drugs including platycarya strobilacea infructescence, spica prunellae, flos chrysanthemi indici, rhizome ligustici wallichii, radix angelicae, flos magnoliae, radix saposhnikoviae, radix astragali and radix glycyrrhizae. The oral drops are reasonable in formula according to the traditional Chinese medicine formula theory; the medicinal materials supplement each other and play a synergistic role; the oral drops are particularly suitable for acute and chronic nasosinusitis and rhinitis of children, and can relieve systemic symptoms, adjust systemic functions and treat locally infected focuses; meanwhile, the natural refined honey is added, so that the effects of strengthening the middle warmer and moistening dryness of the honey can be exerted, the bitter taste of the traditional Chinese medicine can be improved, and the balance of aroma, sweetness, sourness and bitterness of the system is kept; and the oral drops are more suitable for children patients to take.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to an oral drop for children with acute and chronic sinusitis and rhinitis and a preparation method thereof. Background technique [0002] Rhinitis has become a common disease in pediatrics. It is characterized by persistence and relapse. If it is not treated in time and correctly, it may develop secondary diseases and seriously affect the life and study of children. The internal causes of rhinitis are mostly due to the lack of qi in the viscera, especially the lungs, spleen and kidneys; the external causes are responsible for the invasion of cold and heat. [0003] At present, the clinical treatment of this disease is mainly based on western medicine antibiotics. Although there is a certain curative effect, the side effects are relatively large, and drug resistance is easy to develop. Traditional Chinese medicine has its unique advantages in treating rhinitis...

Claims

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Application Information

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IPC IPC(8): A61K36/575A61K9/08A61K47/12A61K47/26A61P11/02A61P29/00A61K35/644
CPCA61K36/52A61K36/536A61K36/287A61K36/236A61K36/232A61K36/575A61K36/238A61K36/481A61K36/484A61K35/644A61K9/0095A61K47/26A61K47/12A61P11/02A61P29/00A61K2236/331
Inventor 李永生唐星姚康宁周伟
Owner GUANGXI XIANGJU PHARMA
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