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Light activated gasotransmitter generating compositions

A technology of composition and photoactivator, which is applied in the direction of drug combination, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve problems such as limited application of nitric oxide

Active Publication Date: 2021-02-09
NOXSANO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of nitric oxide is relatively limited due to the lack of controlled and targeted delivery methods or materials

Method used

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  • Light activated gasotransmitter generating compositions
  • Light activated gasotransmitter generating compositions
  • Light activated gasotransmitter generating compositions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0222] Embodiments related to the present application will be described below. In most cases, alternative techniques can be used. The examples are intended to illustrate, not to define or limit the scope of the invention set forth in the claims.

[0223] Nitric Oxide Photoactivated Wound Preparations

[0224]

[0225]

[0226] To test the above formulations, 10 ppm of 1,2-diaminoanthraquinone was dissolved in the formulations. Formulations were placed in a UV / Vis cell and exposed to full spectrum (white) light. Measure light intensity (lux). UV / Vis spectra were recorded after ten minutes. The reduced intensity of the visible absorption peak at 540 for 1,2-diaminoanthraquinone indicates the production of nitric oxide.

[0227] Hydrogen sulfide photoactivated wound preparation

[0228]

[0229] To test the formulations described above, the formulations were placed in a UV / Vis cell and exposed to full spectrum (white) light. Measure light intensity (lux). Ten...

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Abstract

A composition comprising an organic photoactivator, a gasotransmitter salt which converts into a gasotransmitter via electron transfer, and an electron donor which donates an electron to the photoactivator when the photoactivator is in a photo-excited state.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application Serial No. 62 / 662,573, filed April 25, 2018, which is incorporated herein by reference in its entirety. technical field [0003] The present application provides compositions and methods of treatment using the compositions, dressing articles and systems for applying the compositions to target tissue sites, and in applications suitable for applying the compositions (e.g., medicaments, including, but not limited to) by application of light. A method of generating one or more gaseous transmitters at the site of, without limitation, ointments, salves, creams, etc.), said compositions comprising the generation of one or more gaseous transmitters (including but not limited to nitric oxide and ) of one or more photoactivators. Background technique [0004] Over the past two decades, the importance of gaseous transmitters in biological processes has been ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F13/00A61K33/04C01B17/48
CPCA61P17/02A61P17/10A61K41/00A61K33/00A61N5/062A61N5/0616A61N2005/0661A61K9/0014A01N25/00A61K33/04A61K9/06A61K47/12A61K47/20A61K47/10A61K47/16A61K47/32A61K47/44A61K47/24A61K47/14A61K47/38A61L2/088A01N59/00A01N59/02A61L2/18A61L2/08A61L2202/10A61K41/0057A61L2300/114
Inventor A·威利S·塞缪尔
Owner NOXSANO INC