Composite ruthenium catalyst and its preparation method and application

Abstract

The invention relates to a composite ruthenium catalyst and its preparation method and application. The preparation method of this composite ruthenium catalyst comprises the steps of: dissolving chiral (TS-DPEN) (p-cymene) ruthenium (II) chloride in a solvent, then adding ruthenium carbon catalyst for impregnation, evaporating and removing the solvent, A composite ruthenium catalyst is obtained. The above preparation method pre-prepared composite ruthenium catalyst, compared with the use of equal mass combination of homogeneous catalyst and ruthenium carbon catalyst for chiral synthesis catalysis, thereby speeding up the reaction speed and improving the chiral value of the chiral synthesis product, At the same time, it has low metal ruthenium residue. The use of the pre-prepared composite ruthenium catalyst can greatly reduce the residue of heavy metal ruthenium on the basis of ensuring the conversion rate and chiral value compared with the use of a simple homogeneous catalyst of equal mass for chiral synthesis.

Description

technical field [0001] The invention relates to the technical field of chemical catalysis, in particular to a composite ruthenium catalyst and its preparation method and application. Background technique [0002] Asymmetric synthesis, also known as chiral synthesis, stereoselective synthesis, or enantioselective synthesis, is a branch of organic synthesis that studies chemical reactions in which one or more chiral elements are introduced into reactants. According to Morrison and Mosher's definition, asymmetric synthesis is "an organic reaction in which achiral units in the ensemble of substrate molecules are converted to chiral units by reactants in a way that produces stereoisomeric products in unequal amounts". Here, the reactants can be chemical reagents, catalysts, solvents or physical factors. [0003] Chiral diols are a class of chiral ligands that are widely used, and they are also raw materials for the preparation of chiral diamines, diphosphines and other compounds...

AI Technical Summary

Problems solved by technology

Catalysts are often used in the synthesis of chiral diols, such as ruthenium salt catalysts, but there is a problem that the ruthenium salt catalysts are difficult to separate from the product during use, resulting in a large amount of heavy metal ruthenium residues in the final product

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