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A kind of preparation method of adenosylmethionine succinate for health function

A technology of adenosylmethionine butanedisulfonate and adenosylmethionine, which is applied in the field of preparation of adenosylmethionine butanedisulfonate, can solve the problems of low yield, no application prospect, research on finished products of adenosine butanedisulfonate, and the like. , to achieve the effect of high reaction efficiency, improved catalytic activity and high yield

Active Publication Date: 2022-05-24
内蒙古拜克生物有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, according to its disclosed content, it can be seen that it has not studied the yield of adenosylmethionine succinate. If the purity of the product in actual production is high, but the yield is low, there is still no application prospect

Method used

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  • A kind of preparation method of adenosylmethionine succinate for health function
  • A kind of preparation method of adenosylmethionine succinate for health function
  • A kind of preparation method of adenosylmethionine succinate for health function

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Effect test

Embodiment 1-3

[0031] Embodiment 1-3 A kind of preparation method of adenosine methionine butanedisulfonate for health-care function, comprising the following steps:

[0032] (1) inserting the adenosylmethionine-producing bacteria into the activation medium, the cultivation temperature is 24 ° C, and cultivated for 5 days to obtain an activated strain;

[0033] (2) inoculate the activated bacterial strain obtained in step (1) in the first-class seed medium, the cultivation temperature is 24 ° C, and cultivate for 12 hours to obtain the first-class seed; then the first-class seed is inoculated into the next-class seed medium medium, the cultivation temperature was 24°C, and the cultivation was carried out for 12 hours to obtain secondary seeds;

[0034] (3) insert the secondary seeds obtained in the step (2) into the fermentation medium (the volume of the fermentation liquid is 50 L), the inoculum amount is 25%, the cultivation temperature is 24 ° C, and after 15 hours of fermentation, adenos...

Embodiment 4-6

[0047] Embodiment 4-6 A kind of preparation method of adenosine methionine for health-care function, comprising the following steps:

[0048] (1) inserting the adenosylmethionine-producing bacteria into the activation medium, the cultivation temperature is 32 ° C, and cultivated for 3 days to obtain an activated strain;

[0049] (2) inoculate the activated bacterial strain obtained in step (1) in the first-grade seed medium, the cultivation temperature is 32 ° C, and cultivate for 25 hours to obtain the first-grade seed; then the first-grade seed is inoculated into the next-grade seed medium , the cultivation temperature was 32 °C, and the cultivation was carried out for 25 hours to obtain secondary seeds;

[0050] (3) insert the secondary seeds obtained in the step (2) into the fermentation medium (the volume of the fermentation liquid is 50 L), the inoculation amount is 25%, the cultivation temperature is 32 ° C, and after 20 hours of fermentation, adenosine triphosphate and...

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Abstract

The invention provides a method for preparing adenosylmethionine succinate for health care function, and belongs to the technical field of pharmacy. The present invention adds proline, fumaric acid and Na in the fermented medium with a content ratio of 2-4:1-2:1-2 during implementation. 2 HPO 4 12H 2 O can improve the expression level of adenosylmethionine synthetase, improve the catalytic activity of adenosylmethionine synthetase in organisms, and can ensure that the conversion rate of L-methionine can be improved by adding a lower content of adenosine triphosphate in the fermentation system; the obtained adenosylmethionine The reaction efficiency with succinic acid is high, and the purity of the prepared succinic acid adenosylmethionine product is obviously improved.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a preparation method of adenosine methionine butanedisulfonate for health care function. Background technique [0002] Adenosylmethionine butanedisulfonate is a physiologically active molecule ubiquitous in human tissues and body fluids. It acts as a methyl donor (transmethylation) and a precursor of physiological sulfhydryl compounds (such as cysteine, taurine, glutathione and coenzyme A, etc.) biochemical reaction. It is clinically used for the treatment of depression, arthritis, liver dysfunction and other diseases. It is also suitable for intrahepatic cholestasis before and due to liver cirrhosis, and for intrahepatic cholestasis during pregnancy. Its pharmacological effects are: Adenosylmethionine is a physiologically active molecule that exists in all tissues and body fluids of the human body. It is important in vivo as a methyl donor (transmethylation) and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P19/40C12N1/16C07H19/167C07H1/00C07C303/32C07C309/05C12R1/865
CPCC12P19/40C12N1/16C07H19/167C07H1/00C07C303/32C07C309/05
Inventor 周彦乐杨宝雄郑国强王国强
Owner 内蒙古拜克生物有限公司
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