Fixing device

Abstract

The invention discloses a fixing device. The fixing device comprises a base, a clamping piece, a positioning connecting piece and an elastic piece, wherein the base is provided with an opening, a bearing table used for placing a to-be-measured object and a supporting wall connected with the bearing table; the clamping piece and the supporting wall are arranged in a sliding mode, and the clamping piece operably moves relative to the direction of the bearing table; the bearing table, the supporting wall and the clamping piece form an irradiation area in a surrounding manner, and at least part ofthe clamping piece operably penetrates through an opening of the bearing table to clamp the to-be-measured object and pull a local area of the to-be-measured object to the irradiation area; the positioning connecting piece is used for connecting the clamping piece with the supporting wall and positioning the clamping piece at a preset position of the irradiation area; and the elastic piece is arranged on the clamping piece and is used for operably controlling the clamping piece to clamp or loosen the to-be-measured object. The fixing device can fix skin of an experimental animal in a non-anesthetic state and obtain a skin injury model under the irradiation of radioactive rays, the operate is conveniently, the structure is simple, and the cost is low.

Description

Technical field[0001]The invention relates to the field of experimental equipment, in particular to a fixing device.Background technique[0002]Radiotherapy is one of the most important methods for the treatment of malignant tumors, and skin is the only way to be irradiated. Therefore, while killing tumor cells, it will also damage the skin to varying degrees. At present, there is no research on the specific mechanism of radiation skin damage. Clearly, the main reason is the lack of suitable animal models. Because the current method of modeling radiation skin injury is mainly to irradiate the skin of the legs and back of the mouse after anesthesia, it will inevitably damage the internal organs and bone marrow and other important organs. It is impossible to obtain a simple animal model that only damages the skin. , Causing great interference to the study of radiation skin damage mechanism. And usually before the skin of the mouse is fixed, the mouse needs to be anesthetized. Not only t...

AI Technical Summary

Problems solved by technology

Because the current way of modeling radiation skin injury is to irradiate the skin of the legs and back of mice after anesthesia, which will inevitably damage important organs such as internal organs and bone marrow, and it is impossible to obtain an animal model that only damages the skin , causing great interference to the research on the mechanism of radiation skin damage

And usually before the mouse skin is fixed, it is necessary to anesthetize the mouse. Not only is the whole anesthesia process time-consuming and laborious, but the anesthesia itself has a certain risk of death, and it cannot guarantee that the mouse can wake up 100%. , the breathing of the mice becomes slower and weaker, and the mice will die of suffocation during the process of pulling the skin

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