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Application of glycine in prevention and/or treatment of inflammatory bowel disease

A technology of inflammatory bowel disease and glycine, applied in the field of biomedicine, can solve the problems of side effects, treatment costs, etc.

Inactive Publication Date: 2021-02-26
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these treatment methods have a certain therapeutic effect on inflammatory bowel disease, each method has some shortcomings, such as accompanied by certain side effects or high treatment costs, etc.

Method used

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  • Application of glycine in prevention and/or treatment of inflammatory bowel disease
  • Application of glycine in prevention and/or treatment of inflammatory bowel disease
  • Application of glycine in prevention and/or treatment of inflammatory bowel disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0035] The following examples will use mice as administration objects to verify that glycine can alleviate the symptoms of inflammatory bowel disease induced by Citrobacter in mice, such as weight loss, disease index, spleen hyperplasia, colon shortening, colonic mucosal hyperplasia and colonic inflammation Efficacy in response.

[0036] Unless otherwise specified, the test methods adopted herein are conventional methods, and unless otherwise specified, the test materials used in the following examples are purchased from conventional reagent stores. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the technical field of the invention.

[0037] It should be noted that the terms used in the description of the present invention are only for the purpose of describing specific embodiments, and are not intended to limit the present invention. The summary of the invention above and the d...

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Abstract

The invention belongs to the field of biological medicines, and relates to application of glycine in preventing and / or treating inflammatory bowel diseases. Specifically, the invention finds that theglycine can significantly improve weight loss, disease index increase, spleen proliferation, colon shortening, colonic mucosa proliferation and colitis reaction in an inflammatory bowel disease mousemodel induced by Citrobacter rodentium, and further finds that the glycine can significantly alleviate inflammatory bowel disease of a mouse, and therefore, the glycine is used for development and preparation of drugs for preventing and / or treating the inflammatory bowel diseases. The application of the glycine provides a feasible thought for preventing and / or treating the inflammatory bowel diseases from the perspective of nutrition intervention.

Description

technical field [0001] The invention relates to the field of biomedicine, and relates to the use of glycine in the preparation of medicines for preventing and / or treating inflammatory bowel disease. More specifically, the present invention relates to the use of glycine in the preparation of drugs for improving body weight loss, disease index elevation, spleen hyperplasia, colon shortening, colon mucosal hyperplasia and / or colon inflammatory response induced by Citrobacter rodentium use. Background technique [0002] Inflammatory bowel disease (Inflammatory bowel disease, IBD) is a chronic, easily relapsing gastrointestinal disease, clinical symptoms mainly manifested as abdominal pain, abdominal distension, diarrhea and blood in the stool. In the past few decades, the incidence of inflammatory bowel disease has increased year by year around the world, especially in western countries, which makes inflammatory bowel disease an important public health problem worldwide. [00...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61K31/606A61P1/00A61P29/00
CPCA61K31/198A61K31/606A61P1/00A61P29/00A61K2300/00
Inventor 武振龙张云常杨鹰
Owner CHINA AGRI UNIV
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