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Compositions and methods for diagnosis and treatment of cancer

A technology combining peptides and amino acids, which is applied in the preparation methods of peptides, chemical instruments and methods, botany equipment and methods, etc., can solve the problems of complex functionalization, complex cost-intensive production, and not

Pending Publication Date: 2021-02-26
生物技术欧洲股份公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] To target poorly vascularized tumors, the large size of the antibody or even its fragments may slow down tissue penetration, preventing effective delivery
Furthermore, because of the prolonged blood circulation of antibodies, they do not appear to be optimal for diagnostic use, especially in the case of imaging concepts
In addition to the above, antibody molecular structures with complex glycosylation patterns and disulfide bonds require complex, cost-intensive production and complicate further functionalization, e.g. by imaging tracers

Method used

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  • Compositions and methods for diagnosis and treatment of cancer
  • Compositions and methods for diagnosis and treatment of cancer
  • Compositions and methods for diagnosis and treatment of cancer

Examples

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Embodiment Construction

[0126] While the present invention is described in detail below, it is to be understood that this invention is not limited to the particular methodology, protocols and reagents described herein as these may vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only and not for the purpose of limiting the scope of the invention, which will be limited only by the appended claims. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art.

[0127] Elements of the present invention will be described below. These elements are listed with specific embodiments, however, it should be understood that they may be combined in any manner and in any number to create additional embodiments. The various examples and preferred embodiments described are not to be construed as limiting the invention to only the expressly described ...

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Abstract

The present invention relates to the diagnosis and treatment of diseases expressing Fibronectin Extra Domain B (EDB), such as diseases characterized by tissue remodeling and / or angiogenesis, in particular cancerous diseases, such as head and neck, brain, colorectal, lung, prostate and breast cancer. More particularly, the invention concerns peptides targeting fibronectin extra domain B.

Description

technical field [0001] The present invention relates to the diagnosis and treatment of diseases expressing fibronectin extra domain B (EDB), such as diseases characterized by tissue remodeling and / or angiogenesis, especially cancerous diseases, such as head and neck cancer, brain cancer, colon cancer Colorectal, lung, prostate and breast cancer. More particularly, the present invention relates to peptides targeting the extra domain B of fibronectin. Background technique [0002] Cancer is one of the leading causes of death worldwide, surpassing heart disease. In 2012, 8.2 million people died of cancer worldwide. Classical anticancer therapies, such as radiotherapy, chemotherapy, and conventional surgery, often suffer from poor selectivity and thus severe toxic side effects on healthy tissues. New therapeutic modalities involve the targeted delivery of bioactive molecules (drugs, cytokines, radionuclides, etc.) to the tumor environment via binding molecules specific for tu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/78C12N15/12C12N1/20A61K38/00G01N33/68
CPCC07K14/78C07K7/08C07K14/415C12N15/62G01N33/68G01N33/574A61K38/00A61P35/00C07K2319/00C07K1/1075
Inventor U·沙欣B·G·卢伊N·萨洛蒙J·维斯特胡贝-劳施M·达内施达尔H-U·施莫尔特M·菲德勒
Owner 生物技术欧洲股份公司
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