Application of target site enhancer of rs2280496 or rs189178649

An enhancer and target site technology, applied in the field of biomedicine, can solve problems that cannot fully explain the reasons for platinum drug resistance

Inactive Publication Date: 2021-03-19
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Many studies have reported SNPs associated with sensitivity to platinum-based chemotherapy in non-small cell lung cancer, but these SNPs cannot fully explain the cause of platinum-based drug resistance

Method used

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  • Application of target site enhancer of rs2280496 or rs189178649
  • Application of target site enhancer of rs2280496 or rs189178649
  • Application of target site enhancer of rs2280496 or rs189178649

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Embodiment Construction

[0020] Genome-wide study of sensitivity to platinum-based chemotherapy in non-small cell lung cancer

[0021] We first collected 17 platinum-based chemotherapy-sensitive patients and 17 chemotherapy-resistant patients ( image 3 ) for whole exome sequencing (WES) ( figure 1 a), and the sites with a p-value less than 0.001 in the difference analysis were among 262 non-small cell lung cancer patients with chemotherapy efficacy evaluation ( image 3 ) for verification, the results showed that the rs2293106 gene polymorphism was significantly correlated with the sensitivity to platinum-based chemotherapy in non-small cell lung cancer ( Figure 5 ).

[0022] Meanwhile, in 206 chemotherapy-sensitive and 227 chemotherapy-resistant NSCLC samples ( Figure 4 ) was performed in a genome-wide association analysis (GWAS) ( figure 1 b), and the non-small cell lung cancer platinum-based chemotherapy samples with chemotherapy efficacy evaluation in 347 cases of differential genes ( Fig...

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Abstract

In order to solve the problem of clinical platinum chemotherapy drug resistance of non small cell lung cancer (NSCLC) at present, the invention provides application of a target site enhancer of rs2280496 or rs189178649 in preparation of a platinum chemotherapy sensitization drug for treating NSCLC, and further, the platinum chemotherapy sensitization drug is cis-platinum. The target site enhancercan be used as a novel therapeutic drug for overcoming platinum chemotherapy drug resistance.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to the role of gene rs2280496 or rs189178649 as a target in the preparation of platinum chemotherapy sensitizing drugs for treating non-small cell lung cancer. Background technique [0002] Lung cancer is a common tumor that endangers human life and health in my country and the world. Its morbidity and mortality have been ranking first among all kinds of tumors in recent decades. About 1.6 million people die of lung cancer in the world every year. Lung cancer accounts for about 22.7% of the national cancer deaths in my country. Lung cancer is divided into non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), of which non-small cell lung cancer accounts for about 80%-85% of the total. A lot of research has been done to improve the treatment efficacy of non-small cell lung cancer, but its The 5-year survival rate is still less than 15%. In recent years...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K33/243A61K31/555A61P35/00A61P11/00
CPCA61K45/00A61K33/243A61K31/555A61P35/00A61P11/00
Inventor 陈娟刘俊彦茆晨雪刘昭前尹继业王展
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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