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Pharmaceutical preparation for treating liver and gallbladder damp-heat and preparation method thereof

A pharmaceutical preparation, liver and gallbladder damp-heat technology, applied in the field of pharmaceutical preparations and preparations for the treatment of liver and gallbladder damp-heat, can solve the problem that the treatment effect of liver and gallbladder damp-heat is not as good as that of decoction

Inactive Publication Date: 2021-03-26
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the conventional preparation process, this patent made the traditional Chinese medicine prescription into any conventional dosage form, such as capsules, tablets, etc., but the therapeutic effect on liver and gallbladder damp-heat is not as good as decoction

Method used

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  • Pharmaceutical preparation for treating liver and gallbladder damp-heat and preparation method thereof
  • Pharmaceutical preparation for treating liver and gallbladder damp-heat and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] A preparation method of a medicinal preparation for treating liver and gallbladder damp-heat, the specific steps are as follows:

[0058] (1) First, 1kg Potentilla clover, 1kg Verbena, 0.5kg Imperatae, 0.6kg Pueraria, 0.4kg Desmodium, 0.25kg August Zha, 0.13kg fried red peony, 0.19kg Qingdai, 0.1kg Haijinsha , 0.13kg Epimedium, 0.08kg Bupleurum, 0.1kg Bran Fried Atractylodes Rhizome, 0.07kg Lavender, 0.08kg Chicory, 0.02kg Glycyrrhizae mixed with water decoction extraction, filtered to obtain extract and filter residue;

[0059] (2) Then 4 kg of fried barley and 3 kg of purple rice are pulverized into a mixed powder, which is added to 12 kg of water together with the filter residue, stirred and mixed evenly and sterilized as a fermentation medium, and then inoculated with Candida utilis, Bacillus subtilis, and white ground Mold, ferment, centrifuge to take the supernatant to obtain a fermented liquid, then mix the fermented liquid with the extract obtained in step (1), ...

Embodiment 2

[0082] A preparation method of a medicinal preparation for treating liver and gallbladder damp-heat, the specific steps are as follows:

[0083] (1) First, 1kg Potentilla clover, 1kg Verbena, 0.7kg Imperatae, 0.4kg Pueraria, 0.5kg Desmodium, 0.15kg August Zha, 0.19kg fried red peony, 0.15kg Qingdai, 0.15kg Haijinsha , 0.1kg Epimedium, 0.1kg Bupleurum, 0.07kg Bran Fried Atractylodes Rhizome, 0.09kg Lavender, 0.06kg Chicory, 0.03kg Glycyrrhiza licorice mixed with water decoction, filtered to obtain extract and filter residue;

[0084] (2) Then 2 kg of fried barley and 5 kg of purple rice are crushed into mixed powder, which is added to 10 kg of water together with the filter residue, stirred and mixed and sterilized as a fermentation medium, and then inoculated with Candida utilis, Bacillus subtilis, Mold, ferment, centrifuge to take the supernatant to obtain a fermented liquid, then mix the fermented liquid with the extract obtained in step (1), concentrate, dry, and pulverize ...

Embodiment 3

[0107] A preparation method of a medicinal preparation for treating liver and gallbladder damp-heat, the specific steps are as follows:

[0108] (1) First, 1kg Potentilla clover, 1kg Verbena, 0.6kg Imperatae, 0.5kg Pueraria, 0.43kg Desmodium, 0.2kg August Zha, 0.15kg fried red peony, 0.17kg Qingdai, 0.12kg Haijinsha , 0.12kg Epimedium, 0.09kg Bupleurum, 0.09kg bran fried Atractylodes atractylodes, 0.08kg lavender, 0.07kg chicory, 0.025kg licorice mixed with water decoction extraction, filtered to obtain extract and filter residue;

[0109] (2) Then 3kg of fried barley and 4kg of purple rice are crushed into mixed powder, which is added to 11kg of water together with the filter residue, stirred and mixed evenly and sterilized as a fermentation medium, and then inoculated with Candida utilis, Bacillus subtilis, and white ground Mold, ferment, centrifuge to take the supernatant to obtain a fermented liquid, then mix the fermented liquid with the extract obtained in step (1), conc...

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Abstract

The invention provides a pharmaceutical preparation for treating liver and gallbladder damp-heat and a preparation method thereof. The preparation method comprises the following steps: mixing potentilla anserine, vervain, lalang grass rhizome, radix puerariae, longhairy antenoron herb, fiveleaf akebia fruit, stir-fried radix paeoniae rubra, indigo naturalis, spora lygodii, herba epimedii, radix bupleuri, bran stir-fried rhizoma atractylodis, lavender, endive and liquorice roots in a specific proportion, and carrying out water decoction extraction and filtration to obtain an extracting solutionand filter residues; then crushing fried coix seeds and purple rice to obtain mixed powder, preparing a fermentation culture medium from the mixed powder and the filter residues, inoculating candidautilis, bacillus subtilis and geotrichum candidum, performing fermentation and centrifugation, taking a supernate to obtain fermentation liquor, and mixing the fermentation liquor with the extractingsolution to obtain mixed powder; adding the mixed powder into a hydroxyethyl cellulose-silkworm silk fibroin mixed solution, and carrying out uniform ultrasonic oscillation and drying to obtain an inclusion compound; and finally, mixing the inclusion compound with auxiliary materials to prepare capsules. Compared with a common traditional Chinese medicine decoction, the capsule is convenient to take and has a good treatment effect on liver and gallbladder damp-heat.

Description

technical field [0001] The invention relates to the technical field of preparation of pharmaceutical preparations, in particular to a pharmaceutical preparation for treating liver and gallbladder damp-heat and a preparation method thereof. Background technique [0002] Liver and gallbladder damp-heat syndrome is a general term for a series of symptoms caused by damp-heat cross resistance, abnormal liver and gallbladder dredging, or damp-heat betting along the meridians. Clinical manifestations: yellowing of the body and eyes, distending pain in the flanks, or mass under the flanks, loss of appetite, greasy feeling, general nausea, abdominal distension, irregular stools, short red urine, fever or alternating cold and heat, bitter mouth and dry mouth, Red tongue, yellow and greasy fur, stringy and slippery pulse. Or dampness, pruritus, eczema, swelling and pain in the genitals, thick yellow leukorrhea, etc. More common in acute jaundice hepatitis, gallbladder and bile duct i...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61K9/48A61K47/69A61P1/16
CPCA61K9/4866A61K36/12A61K36/185A61K36/195A61K36/233A61K36/28A61K36/284A61K36/296A61K36/315A61K36/484A61K36/488A61K36/53A61K36/65A61K36/704A61K36/71A61K36/73A61K36/85A61K36/899A61K36/8994A61K2236/19A61K2236/331A61K2236/39A61K47/6949A61P1/16A61K2300/00
Inventor 王志刚邱时孔玲郑智洋赵雨欣周新茹赵超凡郝奥林刘斌张宁王发善
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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