A biomarker and its application in the diagnosis of cerebral infarction
A biomarker and cerebral infarction technology, applied in the field of biomedicine, can solve problems such as high mortality and disability, sudden onset, threats to human health and life, and achieve the effect of improving the quality of life
Active Publication Date: 2022-05-27
THE SECOND HOSPITAL OF HEBEI MEDICAL UNIV
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Problems solved by technology
Acute cerebral infarction (Acute cerebral infarction, ACI) is also defined as acute ischemic stroke, and the main subtypes of acute cerebral infarction worldwide are divided into atherosclerotic cerebral infarction (Atherosclerotic cerebral infarction), cardiogenic cerebral embolism (Cardiogenic cerebral embolism) and lacunar infarction (Iacunar infarction), due to the sudden onset and rapid progression of acute cerebral infarction, resulting in high mortality and disability, it threatens the health and life of human beings. The whole society brings a heavy burden, and because the complications caused by acute cerebral infarction often seriously increase the family burden of patients and reduce the quality of life of patients, it has become the focus and difficulty of research in the field of medicine and health
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[0063] The present invention will be described in further detail below with reference to the accompanying drawings and embodiments. The following examples are only used to illustrate the present invention and not to limit the scope of the present invention. The experimental methods that do not specify specific conditions in the examples are usually in accordance with conventional conditions.
[0064] Example Screening and efficacy judgment of cerebral infarction-related metabolites
[0065] 1. Sample collection
[0066] Blood samples from 21 patients with cerebral infarction and 18 healthy controls were collected.
[0067]Inclusion criteria for cerebral infarction group:
[0068] 1) Subjects have signed informed consent
[0069] 2) Meet the diagnostic criteria for acute cerebral infarction in "China Guidelines for Diagnosis and Treatment of Acute Ischemic Stroke (2014 Edition)".
[0070] 3) Age 18-65 years old.
[0071] 4)BMI 18.5-23.9kg / m 2 .
[0072] 5) Blood routine...
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Abstract
The invention discloses a biomarker and its application in the diagnosis of cerebral infarction, specifically disclosing the biomarker PC (14:0 / 18:2(9Z,12Z)), compared with healthy controls, the PC (14:0 / 18:2(9Z,12Z)) was reduced in the level of cerebral infarction, and PC(14:0 / 18:2(9Z,12Z)) was used as the detection variable, which had a higher ability to distinguish cerebral infarction from healthy controls effectiveness.
Description
technical field [0001] The invention belongs to the field of biological medicine, and relates to a biological marker and its application in the diagnosis of cerebral infarction. Background technique [0002] With the aggravation of the aging population, the continuous improvement of people's living standards, the changing diet structure with social changes and regional differences, and even the worsening of bad habits such as staying up late, alcoholism, smoking, etc., cardiovascular and cerebrovascular diseases The harm caused by people has become more and more serious, so that the incidence of such diseases in the population has been on the rise year after year. Among them, stroke is one of the most common causes of disability and death in humans. Studies have confirmed that the number of deaths due to stroke is the second largest cause of death in the world (Zongping F, Jiao D, Zhixin W, et al. Cystatin C Is a Crucial Endogenous Protective Determinant Against Stroke [J]....
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IPC IPC(8): G16H50/20G16H50/50G16H10/40G01N30/02G01N30/72G01N30/86G01N30/88G01N24/08G01N21/31G01N27/62
CPCG16H50/20G16H50/50G16H10/40G01N30/02G01N30/72G01N30/8634G01N30/8696G01N30/88G01N24/082G01N21/31G01N27/62G01N2030/8813
Inventor 张祥建张聪张培培
Owner THE SECOND HOSPITAL OF HEBEI MEDICAL UNIV