A Nanoparticle Screening and Separation Device Based on Scanning Optical Tweezers

Abstract

The invention relates to a device for screening and separating nanoparticles based on scanning optical tweezers. The device includes: a laser, an integrated acousto-optic deflector AOD, a beam expander, a dichroic mirror, a microscope, a sample chamber, an illumination source, a reflection Mirror, condenser lens and CCD camera; the laser beam emitted by the laser is sequentially modulated by the AOD, expanded by the beam expander, coupled by the dichroic mirror and vertically injected into the inverted microscope, and then passed through the inverted microscope The microscope is focused into the sample chamber; an illumination source is arranged above the inverted microscope, and the illumination source passes through the inverted microscope and the dichroic mirror, and is reflected by the reflector and converged by the condenser to the CCD camera middle. The above-mentioned device in the present invention does not need to rely on the fabrication of other micro-devices, as long as it is based on scanning optical tweezers and only needs to change the scanning frequency to realize bidirectional sorting.

Description

technical field [0001] The invention relates to the field of nanoparticle screening, in particular to a nanoparticle screening and separation device based on scanning optical tweezers. Background technique [0002] Nanoparticles have unique optical and chemical properties and play an increasingly important role in many fields of applications. The common optical manipulation of nanoparticles has a wide range of applications in surface science, colloid chemistry, microfluidics, biochemistry, and medicine. Such as drug delivery, nanoscale lithography and other fields. However, the optical properties of nanoparticles depend largely on their size and shape, and the precision requirements for the size of nanoparticles are also different in different application fields. Therefore, it is very important to study the sorting of nanoparticles with different sizes. necessary. However, many synthetic methods often produce large size differences, or have high requirements for the opera...

AI Technical Summary

Problems solved by technology

[0004] Although the all-optical sorting method can minimize the damage to the sample, most of the reported optical sorting studies have certain limitations: for general dielectric particles, the separation range of optical chromatography Wide span, low precision, mostly in the micron range, and high prerequisite requirements, for example, if the sample particles are dispersed in the solution but not arranged, the trajectory changes are not obvious, and the separation effect is not shown

That said, it is difficult to apply to the general case

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