Nanoparticle screening and separating device based on scanning type optical tweezers

Abstract

The invention relates to a nanoparticle screening and separating device based on scanning type optical tweezers. The device comprises a laser device, an integrated acousto-optic deflector AOD, a beam expander, a dichroscope, a microscope, a sample chamber, an illumination light source, a reflector, a collecting lens and a CCD camera, wherein a laser beam emitted by the laser device is vertically emitted into the inverted microscope through AOD modulation, beam expansion by the beam expander and coupling of the dichroscope in sequence, and is focused into the sample chamber through the inverted microscope; the illumination light source is arranged above the inverted microscope, penetrates through the inverted microscope and the dichroscope, is reflected by the reflector and is converged into a CCD camera through the condenser. The device provided by the invention does not depend on manufacturing of other micro devices, and bidirectional sorting can be realized only based on the scanning optical tweezers and only by changing the scanning frequency.

Description

technical field [0001] The invention relates to the field of nanoparticle screening, in particular to a nanoparticle screening and separation device based on scanning optical tweezers. Background technique [0002] Nanoparticles have unique optical and chemical properties and play an increasingly important role in many fields of applications. The common optical manipulation of nanoparticles has a wide range of applications in surface science, colloid chemistry, microfluidics, biochemistry, and medicine. Such as drug delivery, nanoscale lithography and other fields. However, the optical properties of nanoparticles depend largely on their size and shape, and the precision requirements for the size of nanoparticles are also different in different application fields. Therefore, it is very important to study the sorting of nanoparticles with different sizes. Needed. However, many synthetic methods often produce large size differences, or have high requirements for the operatin...

AI Technical Summary

Problems solved by technology

[0004] Although the all-optical sorting method can minimize the damage to the sample, most of the reported optical sorting studies have certain limitations: for general dielectric particles, the separation range of optical chromatography Wide span, low precision, mostly in the micron range, and high prerequisite requirements, for example, if the sample particles are dispersed in the solution but not arranged, the trajectory changes are not obvious, and the separation effect is not shown

That said, it is difficult to apply to the general case

Images