Styela plicata-derived fungus and application thereof

A technology of fungi and sources, applied in the direction of medical raw materials derived from fungi, fungi, microorganisms, etc., can solve the problems of plant extract drug stability and quality uniformity, drug resistance, and unsatisfactory treatment effects, etc. Achieve good development prospects, not destroy the ecological balance, easy to achieve the effect of industrialization
CN112646729AActive Publication Date: 2021-04-13SUN YAT SEN UNIV
6 Cites 5 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUN YAT SEN UNIV
Publication Date
2021-04-13

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention belongs to the technical field of fungus biological medicine application, and particularly relates to a styela plicata-derived fungus and application thereof. The styela plicata-derived fungus, Beauveria felina fungus strain SYSU-MS7908, can be metabolized to synthesize a pyridine-containing novel skeleton meroterpenoid compound--amphichoterpenoid. Experimental verification shows that the compound has remarkable acetylcholinesterase activity resistance, and has a good development prospect in the preparation of medicines for preventing and / or treating acetylcholinesterase-mediated diseases; and modern microbial fermentation engineering technology is used for reproduction, and worries about raw materials are avoided. Meanwhile, the invention has the advantages that ecological balance is not destroyed, industrialization is easy to achieve, etc. The styela plicata-derived fungus is a renewable drug resource with development prospects, and abundant raw materials are provided for research and development of marine microbial products and marine microbial drugs.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical field of fungal biomedical application. More specifically, it relates to a sea squirt-derived fungus and its application. Background technique

[0002] Alzheimer's disease (Alzheimer disease, AD) is a kind of central nervous system degenerative disease characterized by progressive cognitive dysfunction and behavioral damage, mainly occurs in the elderly, commonly known as senile dementia. With the acceleration of the aging society, AD has become an important threat to human health, which belongs to the category of clinical medical problems and major diseases. Studies have found that acetylcholinesterase inhibitors (AChEI) are the main anti-AD therapeutic drugs, mainly by inhibiting excessive acetylcholinesterase (AChE) activity and directly acting on the cholinergic system to achieve the effect of treating neurodegenerative diseases such as AD. Purpose.

[0003] At present, about five drugs for the treatment of...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More