Colloidal capsule embedded with micromolecular hydrophilic components and preparation method thereof

A hydrophilic, small-molecule technology, applied in the direction of microcapsule preparation, microsphere preparation, etc., can solve the problems of low embedding rate, low loading capacity, poor stability, etc., and achieve good repeatability, enhanced structural performance, and preparation conditions mild effect

Active Publication Date: 2021-04-16
CHINA WEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention provides a colloid capsule with high embedding rate and high loading capacity for embedding small molecule hydrophilic components and its preparation method to enhance its structural performance , and solve the shortcomings and deficiencies of the existing microencapsulation technology, such as low embedding rate of small molecule hydrophilic components, low loading capacity, poor stability, etc.

Method used

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  • Colloidal capsule embedded with micromolecular hydrophilic components and preparation method thereof
  • Colloidal capsule embedded with micromolecular hydrophilic components and preparation method thereof
  • Colloidal capsule embedded with micromolecular hydrophilic components and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0043] Such as figure 1 Shown, a kind of preparation method of the colloid capsule of embedding vitamin C comprises the steps:

[0044] (1) Add 0.1g alginic acid and 0.2g kappa-type carrageenan to 10g pure water, stir at room temperature to obtain a clear and transparent alginic acid / carrageenan mixed solution; add 2g vitamin C to 10g glacial acetic acid aqueous solution (0.2%, w / v), stirred at room temperature in the dark to obtain vitamin C solution;

[0045] (2) Add 0.1g of modified nano-calcium carbonate and 0.14g of Span 80 to 6.8g of castor oil respectively, and stir fully in a constant temperature water bath at 50°C to obtain a castor oil dispersion containing modified nano-calcium carbonate and Span 80 liquid;

[0046] (3) Add 2.2g alginic acid / carrageenan mixed solution dropwise to the castor oil dispersion containing modified nano calcium carbonate particles and Span 80 under stirring at 1500rpm, stir at 50°C for 10min, then add 0.5g vitamin C solution, continue t...

Embodiment 2

[0061] A preparation method for colloidal capsules embedding tea polyphenols, comprising the steps of:

[0062] (1) Add 0.25g of alginic acid and 0.1g of λ-type carrageenan to 10g of pure water, stir at room temperature to obtain a clear and transparent mixed solution of alginic acid / carrageenan; add 0.5g of tea polyphenols to 10g of ice Acetic acid aqueous solution (0.2%, w / v), stirring at room temperature in the dark to obtain a tea polyphenol solution;

[0063] (2) Add 0.15g of modified nano-calcium carbonate and 0.1g of Span 20 to 6.75g of castor oil respectively, and stir fully in a constant temperature water bath at 55°C to obtain a castor oil dispersion containing modified nano-calcium carbonate and Span 20 liquid;

[0064] (3) Add 2.2 g of alginic acid / carrageenan mixed solution dropwise to the castor oil dispersion containing modified nano-calcium carbonate particles and Span 20 under stirring at 1500 rpm, stir at 55° C. for 10 min, and then add 0.5g tea polyphenol ...

Embodiment 3

[0073] A preparation method for colloidal capsules embedding oligomeric proanthocyanidins, comprising the steps of:

[0074] (1) Add 0.15g of alginic acid and 0.2g of κ-type carrageenan to 10g of pure water, stir at room temperature to obtain a clear and transparent mixed solution of alginic acid / carrageenan; add 2.2g of oligomeric proanthocyanidins to 10g of ice Acetic acid aqueous solution (0.1%, w / v), stirring at room temperature in the dark to obtain an oligomeric proanthocyanidin solution;

[0075] (2) Add 0.12g of modified nano-calcium carbonate and 0.08g of polyglycerol castor oil to 6.75g of castor oil respectively, and stir fully in a constant temperature water bath at 52°C to obtain modified nano-calcium carbonate and polyglycerol castor oil Castor oil dispersion of alcohol esters;

[0076] (3) Add 2.2g alginic acid / carrageenan mixed solution dropwise to the castor oil dispersion containing modified nano-calcium carbonate particles and polyglycerol ricinoleate under...

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Abstract

The present invention discloses a colloidal capsule embedded with micromolecular hydrophilic components and a preparation method thereof. The preparation method comprises the following steps: firstly, emulsifying an alginic acid / carrageenan mixed solution containing the micromolecular hydrophilic components and castor oil containing modified nano calcium carbonate particles to form a water / oil emulsion in which nano particles are stable at a two-phase interface; and then adding a glucolactone solution and a potassium chloride solution to carry out cross-linking immobilization on alginic acid / carrageenan in the inner water phase, so as to prepare the colloidal capsule embedded with the micromolecular hydrophilic component. The colloidal capsule capable of embedding the micromolecular hydrophilic component, provided by the invention, is high in encapsulation efficiency and large in loading capacity, and can also realize the activity stability of the micromolecular hydrophilic component in long-term storage. Besides, the colloidal capsule prepared by the method is good in sphericity degree and has a colloidal shell wall structure formed by one or more layers of modified nano calcium carbonate, so that the defect that only biomacromolecule components can be embedded due to high permeability of the shell wall structure in the past is overcome, and the application range of the colloidal capsule is greatly widened.

Description

technical field [0001] The invention belongs to the technical field of preparation of microcapsules, and in particular relates to a colloid capsule embedding small molecular hydrophilic components and a preparation method thereof. Background technique [0002] Colloidal capsules are a new type of microcapsules with colloidal particles as the shell wall structure. This is because the colloidal particles can self-assemble at the oil-water interface of Pickering emulsion to form an ordered spherical colloidal shell. Compared with traditional microcapsules, colloidal capsules are more stable in structure, which is mainly reflected in two aspects: (1) High mechanical properties, which mainly depend on the thickness and compactness of the shell wall formed by the colloidal particles assembled by the ordered interface. (2) thermal stability is good, and this is because most of the colloidal particles that can be used to prepare colloidal capsules are inorganic particles at present,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02B01J13/04
CPCY02W90/10
Inventor 王强
Owner CHINA WEST NORMAL UNIVERSITY
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