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Perfusion bioprocessing system and method of operating the same

A biological treatment, bioreactor technology, applied in the field of perfusion biological treatment system, operation perfusion biological treatment system, can solve the problems of blockage duration, filter efficiency reduction, increase processing time and so on

Pending Publication Date: 2021-04-23
CYTIVA SWEDEN AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a result, filter efficiency decreases due to filter clogging, which in turn affects filtration quality, loss of control over the continuous process, and increases overall process time
In scenarios where tangential flow filters are used for continuous processing, filter clogging limits the duration during which the process can run without interruption
In particular, filter clogging limits the duration of perfusion and limits the achievable cell density at the end of the procedure
Furthermore, the tangential flow filter would need to be changed manually, resulting in a process stop for filter replacement

Method used

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  • Perfusion bioprocessing system and method of operating the same
  • Perfusion bioprocessing system and method of operating the same

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Embodiment Construction

[0012] Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. As used herein, the terms "first," "second," etc. do not denote any order, quantity, or importance, but are used to distinguish one element from another. Furthermore, the terms "a" and "an" do not denote a limitation of quantity, but rather the presence of at least one of the referenced items. The use of "comprises," "including," or "having" and variations thereof herein is intended to encompass the items listed thereafter and equivalents thereof as well as additional items.

[0013] According to an embodiment of the present specification, a method for operating a perfusion bioprocessing system is disclosed. The method includes causing a first amount of process fluid to flow from the bioreactor to a first tangential flow filter via a recirculation flow path. The method also includes oper...

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PUM

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Abstract

A perfusion bioprocessing system (10) includes a bioreactor (12) and a recirculation flow path (14) provided with at least one first feed flow control device (46) and at least one second feed control device(48). The perfusion bioprocessing system (10) further includes a first tangential flow filter (16) coupled to the bioreactor (12) via the recirculation flow path (14) and a second tangential flow filter (18) coupled to the bioreactor (12) via the recirculation flow path(14). The first tangential flow filter and the second tangential flow filter are coupled to a permeate flow path and a retentate flow path. Additionally, the perfusion bioprocessing system (10) includes a control unit (90) coupled to the at least one first feed flow control device (38) and the at least one second feed control device (40).

Description

technical field [0001] Embodiments of the present specification relate generally to filtration systems, and more particularly to a perfusion bioprocessing system having a plurality of tangential flow filters and a method for operating a perfusion bioprocessing system. Background technique [0002] The existence of many substances as solutions or mixtures creates a need to develop processes for separating solutions or mixtures. The need to purify, recover, separate and remove substances in process streams in chemical, pharmaceutical, food, petroleum, healthcare and wastewater applications drives the need for separation technologies. [0003] The most common filtration processes are microfiltration (MF), ultrafiltration (UF) and reverse osmosis (RO). Such filtration processes are pressure driven and are used to separate macromolecules from fluids using filters. Filters act as selective barriers by allowing certain components of the mixture to pass while retaining other compo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D61/22C12M1/26C12M1/00
CPCB01D61/22B01D2311/2688B01D2315/14B01D2317/04B01D2315/18C12M47/10C12M29/10C12M29/04B01D2311/253B01D61/12B01D2315/10C12M41/40C12M41/44C02F2209/00C02F2209/001C02F2209/005C02F2209/40
Inventor P·鲍尔P·H·莫翰A·高雷S·阿拉古尔
Owner CYTIVA SWEDEN AB