Mometasone furoate emulsifiable paste and preparation method thereof

A technology of mometasone furoate cream and mometasone cream, which is applied in directions such as ointment delivery, pharmaceutical formulation, emulsion delivery, etc., can solve the problems of waste, low yield, low yield and the like, and achieves good stability, The effect of high yield and reduced impurity content

Active Publication Date: 2021-05-07
GUANGZHOU BAIYUNSHAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the mometasone furoate cream prepared by the existing prescription and process has a high impurity content, and the yield in the production process is very low, resulting in great waste
In view of this, the application provides a mometasone furoate cream and a preparation method thereof, focusing on solving the problems of high impurity content and low yield in the prior art

Method used

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  • Mometasone furoate emulsifiable paste and preparation method thereof
  • Mometasone furoate emulsifiable paste and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-5

[0057] Wherein, the formula of embodiment 1-5 is as shown in table 1:

[0058] Table 1.

[0059]

[0060] Embodiment 1-5 is all prepared according to the following steps:

[0061] Step 1, the preparation of the oil phase: weigh cetostearyl alcohol, light liquid paraffin, glyceryl mono- and distearate by weight and place them in the oil phase heating tank, open the interlayer steam and heat to 85°C, stir and dissolve, 85 ℃ heat preservation standby;

[0062] Step 2, preparation of the water phase: weigh purified water, glycerin, and polysorbate 80, which is half of the prescription amount, and place it in the water phase heating tank, turn on the interlayer steam and heat to 85°C, stir evenly, and keep warm at 85°C spare;

[0063] Step 3, the preparation of phosphoric acid solution: take phosphoric acid by weight, add purified water to make 1.0% phosphoric acid solution, set aside;

[0064] Step 4, the preparation of the main drug solution: take the remaining part of pol...

Embodiment 6

[0071] Different from Example 1, step 5 is specifically:

[0072] a Pump the water phase into a vacuum emulsifier, add titanium dioxide, stir to make it evenly dispersed, and keep it warm at 85°C for later use;

[0073] b. Pump the oil phase into the vacuum emulsifier, start the homogenizer (2550rpm, 10 minutes), and at the same time stir slowly (80rpm, 10 minutes) to make an emulsion-type matrix, cool down to 50°C-55°C, and keep warm;

[0074] c. Pump the 1.0% phosphoric acid solution into the vacuum emulsifier, start the homogenizer (2550rpm, 5 minutes), and at the same time stir slowly (80rpm, 5 minutes), keep warm at 50°C-55°C;

[0075] d Pump the main ingredient solution into the vacuum emulsifier, stir evenly, start the homogenizer (2550rpm, 5 minutes), and at the same time stir slowly (80rpm, 10 minutes), cool to below 50°C and stir out the paste.

[0076] It is found in the experiment that at this homogenization speed, the paste is viscous, has no fluidity, and is dif...

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Abstract

The invention discloses mometasone furoate emulsifiable paste and a preparation method thereof, and belongs to the technical field of external pharmaceutical preparations. The mometasone furoate emulsifiable paste comprises the following components in parts by weight: 0.5 to 2 parts of mometasone furoate, 0.2 to 0.4 part of acid, 75 to 150 parts of an oil phase regulator, 30 to 50 parts of a consistency regulator, 60 to 100 parts of a humectant, 80 to 120 parts of a co-emulsifier, 60 to 90 parts of a cosolvent, 1 to 3 parts of a whitening agent, 30 to 50 parts of an emulsifier, 0.3 to 1 part of a preservative and 495 to 605 parts of water. The preparation method disclosed by the invention is advanced in process, and simple and easy to operate, and the prepared mometasone furoate emulsifiable paste is reduced in impurity content, high in yield and good in stability.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations for external use, and in particular relates to a mometasone furoate cream and a preparation method thereof. Background technique [0002] Topical corticosteroids are anti-inflammatory, antipruritic, and vasoconstrictor and are used to relieve redness, skin edema (swelling), itching, skin changes in psoriasis, atopic dermatitis (atopic eczema), other skin conditions Hard, flaking, blistering, cracking, oozing, and discomfort, among others, including contact dermatitis, seborrheic dermatitis, eczema xeroderma, discoid eczema, venous eczema, dermatitis herpetiformis, neuropathic Dermatitis, autologous eczema, etc. Mometasone furoate is a kind of corticosteroid, which is a synthetic glucocorticoid drug. Mometasone furoate cream has the effect of relieving inflammation and itching, and is suitable for skin diseases that are effective for glucocorticoids. It has strong curative effe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/10A61K47/26A61K47/04A61K47/14A61K31/58A61P17/00A61P17/04A61P29/00
CPCA61K9/06A61K9/0014A61K47/10A61K47/26A61K47/02A61K47/14A61K31/58A61P17/00A61P17/04A61P29/00Y02A50/30
Inventor 朱岁华陈溪谢华金黄芷茵周洁高燕陈贤安唐九歌王智森
Owner GUANGZHOU BAIYUNSHAN PHARM CO LTD
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