Application of baeckea frutescens extract in preparation of medicine for treating cervicitis

Abstract

The invention discloses application of a baeckea frutescens extract in preparation of a medicine for treating cervicitis. According to the application, it is found for the first time that BF-ext can obviously improve the condition of uterine wall mucosa damage and reduce the level of TNF-alpha and IL-6. A safe and effective treatment method can be provided for cervicitis, and clues and basis are provided for drug development.

Description

technical field

[0001] The present invention relates to the treatment of cervicitis of a kind of pine extract BF-ext. Background technique

[0002] Cervicitis is a common disease of the female reproductive system. The patients are generally women of childbearing age. It is related to the inflammation in the uterine tissue. When the inflammatory infiltration increases, if it is not treated in time, it may develop into serious sequelae, and the adhesion of reproductive organ tissue will occur. , hyperplasia. The clinical manifestations of cervicitis mainly include chronic pelvic pain, dysmenorrhea, infertility and so on. The incidence of cervicitis is on the rise and it is difficult to cure, which seriously threatens the physical and mental health of patients. At present, antibiotics combined with hormone therapy are commonly used clinically, which can effectively kill pathogens, but long-term use has many adverse reactions and is prone to drug resistance. Studies have show...

Examples

Embodiment 1

[0022] 1. Experimental materials

[0023] Reagents: phenol mucilage, Fukeqianjin tablets (Zhuzhou Qianjin Pharmaceutical Co., Ltd.), tumor necrosis factor-ɑ (TNF-ɑ), interleukin-6 (IL-6) enzyme-linked adsorption reaction (ELISA) kit (Lianke Biological Technology Co., Ltd)

[0024] Preparation of Pinus pinus extract BF-ext: The dry aerial part of Pinus pinus pinus (1 kg) was pulverized and extracted twice with 95% ethanol under reflux for 2 hours. The combined extracts were concentrated under reduced pressure to obtain a residue (30 g), which was further suspended in water and separated with petroleum ether (60-90° C.), chloroform and n-butanol successively. The petroleum ether fractions were collected and evaporated in vacuo at 60°C to give dried Pinus pine (8.0 g) extract BF-ext.

[0025] 2. Experimental method

[0026] Animal grouping and modeling: 32 female Kunming mice were randomly divided into control group, model group, Fukeqianjin Tablet (1g / kg) group and BF-ext (10...

technical field

[0001] The present invention relates to the treatment of cervicitis of a kind of pine extract BF-ext. Background technique

[0002] Cervicitis is a common disease of the female reproductive system. The patients are generally women of childbearing age. It is related to the inflammation in the uterine tissue. When the inflammatory infiltration increases, if it is not treated in time, it may develop into serious sequelae, and the adhesion of reproductive organ tissue will occur. , hyperplasia. The clinical manifestations of cervicitis mainly include chronic pelvic pain, dysmenorrhea, infertility and so on. The incidence of cervicitis is on the rise and it is difficult to cure, which seriously threatens the physical and mental health of patients. At present, antibiotics combined with hormone therapy are commonly used clinically, which can effectively kill pathogens, but long-term use has many adverse reactions and is prone to drug resistance. Studies have show...

Examples

Embodiment 1

[0022] 1. Experimental materials

[0023] Reagents: phenol mucilage, Fukeqianjin tablets (Zhuzhou Qianjin Pharmaceutical Co., Ltd.), tumor necrosis factor-ɑ (TNF-ɑ), interleukin-6 (IL-6) enzyme-linked adsorption reaction (ELISA) kit (Lianke Biological Technology Co., Ltd)

[0024] Preparation of Pinus pinus extract BF-ext: The dry aerial part of Pinus pinus pinus (1 kg) was pulverized and extracted twice with 95% ethanol under reflux for 2 hours. The combined extracts were concentrated under reduced pressure to obtain a residue (30 g), which was further suspended in water and separated with petroleum ether (60-90° C.), chloroform and n-butanol successively. The petroleum ether fractions were collected and evaporated in vacuo at 60°C to give dried Pinus pine (8.0 g) extract BF-ext.

[0025] 2. Experimental method

[0026] Animal grouping and modeling: 32 female Kunming mice were randomly divided into control group, model group, Fukeqianjin Tablet (1g / kg) group and BF-ext (10...

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