Acne-removing composition and preparation method of emulsion thereof

A composition and anti-acne technology, which can be used in drug combinations, skin care preparations, medical preparations containing active ingredients, etc., can solve the problems of high skin irritation, low purity of active ingredients, complex ingredients, etc., and achieve anti-inflammation Strong activity, good therapeutic effect, clear content effect

Inactive Publication Date: 2021-05-11
JIANGSU HIGH WIT BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The present invention aims at the existing anti-acne products that are highly irritating to the skin, contain complex ingredients, and have low purity of active ingredients. Long-term use is not conducive to the normalization of skin functions and may cause complications of skin problems. It provides an acne-removing composition and The preparation method of the emulsion containing the acne-removing composition aims at restoring the normal physiological function of the skin based on the occurrence mechanism of acne, and has clear ingredients, appropriate content and low irritation

Method used

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  • Acne-removing composition and preparation method of emulsion thereof
  • Acne-removing composition and preparation method of emulsion thereof
  • Acne-removing composition and preparation method of emulsion thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0050] This embodiment provides an O / W emulsion of an acne-removing composition composed of silybin, azelaic acid, nicotinamide, silver ions, royal jelly, and the like.

[0051] The specific implementation steps are as follows, and the distribution ratio of each group is shown in Table 1.

[0052] Step 1: Add water, humectant, and thickener to the water phase pot, stir and heat up to 70°C, keep warm and stir for 30 minutes, and mix all components evenly to form a water phase;

[0053] Step 2: Add solid oil and emulsifier cetyl alcohol, polyglyceryl-6 stearate, polyglyceryl-6 caprate, glyceryl monostearate into the cold pot, add silybin and mix for 10 minutes Finally, silybin is evenly dispersed in the middle of the solid oil, and the rest of the liquid oil is added under stirring, and the temperature is raised to 70 degrees until it is completely dissolved and homogenized at 12000rpm for 5 minutes;

[0054] Step 3: Pump the oil phase and the water phase into the emulsificatio...

Embodiment 2

[0065] Example 2, Efficacy Evaluation Experiment of Acne Removing Composition and Its Emulsion

[0066] 1. Embodiment 1 stoste preparation

[0067] Prepare 41 mg / ml stock solution of Example 1 with silybin, niacinamide, azelaic acid, royal jelly oil control factor, and silver ion at a ratio of 1:1:1:1:0.1 and DMSO as a solvent, and dilute it 104 times with deionized water Obtain No. 1 stock solution of 4.1 μg / ml Example 1, obtain No. 2 stock solution of 0.41 μg / ml Example 1 after diluting 105 times with deionized water, obtain No. 3 stock solution of 0.041 μg / ml Example 1 after diluting 106 times, dilute 107 After doubling, No. 4 0.0041 μg / ml stock solution of Example 1 was obtained.

[0068] 2. Embodiment 1 emulsion preparation

[0069] The emulsion was prepared by adding 3% of silybin, 3% of nicotinamide, 3% of azelaic acid, 3% of oil-controlling factor of royal jelly and 3ppm of silver ion.

[0070] 3. Anti-inflammatory test of lipopolysaccharide LPS-induced RAW264.7 mou...

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Abstract

The invention discloses an acne-removing composition and a preparation method of an emulsion thereof. The acne-removing composition comprises the following components in percentage by mass: 2-6% of nicotinamide, 0.1-4% of silybin, 1-5ppm of silver ions, 1-3% of royal jelly, 0.5-5% of azelaic acid and the balance water. According to the acne-removing composition disclosed by the invention, the active ingredients in the formula are reasonably combined according to the acne occurrence mechanism, and the form, concentration, adding method and adding sequence of the raw materials are properly selected according to the characteristics of the active ingredients. Meanwhile, the preparation process is optimized, the loss of the active ingredients is reduced, and the formula stability is improved. The antibacterial activity, lipase inhibition activity and anti-inflammatory activity of each component are extremely high, and the acne treatment effect is good. In the aspect of controllable quality, the formula components are simplified and clear in content, and the condition that the quality is uncontrollable easily caused by compounding multiple traditional Chinese medicine extracts in like products is avoided.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to an acne-removing composition composed of silibinin, azelaic acid, nicotinamide, silver ions, royal jelly and a preparation method thereof for an O / W emulsion. Background technique [0002] Acne, also known as "pimples", "comedones" or "acne", is a chronic inflammatory skin disorder involving the sebaceous unit. It is characterized by abnormal sebum secretion, desquamation of the hair follicle epithelium, bacterial proliferation, inflammation and immune host response. It usually occurs on the face, chest, upper back and neck area. Acne can severely impact a patient's social and psychological life. [0003] The pathogenesis of acne can be divided into four stages: [0004] 1. The sebaceous glands over-secrete sebum, and the hair follicle mouth deposits to form a fat plug, that is, open acne; [0005] 2. Excessive keratinization of epidermal cells leads to the formation of clo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/67A61K8/49A61K8/362A61K8/19A61Q19/00A61Q17/00A61P29/00A61P17/00A61K8/39A61K8/37
CPCA61K8/675A61K8/498A61K8/362A61K8/19A61Q17/005A61Q19/00A61P29/00A61P17/00A61K8/39A61K8/375A61K2800/782A61K2800/524A61K2800/592
Inventor 刘建平王莎莎杨政
Owner JIANGSU HIGH WIT BIOTECH CO LTD
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