A kind of tilmicosin premix and preparation method thereof

A technology of tilmicosin and premix, which is applied in the field of tilmicosin premix and its preparation, can solve problems such as not paying attention to irritation, and achieve long-term stability, bioavailability, and dissolution stability sexual effect

Active Publication Date: 2021-10-15
GUANGZHOU HESHENGTANG ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the preparation is stable, the preparation process is simple, and it is convenient to use, but the application does not pay attention to the irritation to the stomach

Method used

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  • A kind of tilmicosin premix and preparation method thereof
  • A kind of tilmicosin premix and preparation method thereof
  • A kind of tilmicosin premix and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0037] Embodiment 1 a kind of tilmicosin premix and preparation method thereof

[0038] The composition comprises the following components in parts by weight: 15 parts of tilmicosin, 5 parts of flavoring agent, 15 parts of microcrystalline cellulose sodium, 10 parts of corn starch, 20 parts of food attractant and 8 parts of acrylic resin.

[0039] The attractant is L-alanine, L-aspartic acid and betaine with a mass ratio of 2:2:1.

[0040] The preparation method of described tilmicosin premix comprises the following steps:

[0041] (1) After mixing the flavoring agent, microcrystalline cellulose sodium, cornstarch and tilmicosin, add an appropriate amount of water and stir to obtain a uniform wet material;

[0042] (2) The wet material obtained in the step (1) is extruded and rounded to obtain a tilmicosin wet pellet core;

[0043] (3) Coating, sizing and drying the tilmicosin wet pellet core obtained in step (2) by using a mixed solution of 5% acrylic resin and an attractan...

Embodiment 2

[0044] Embodiment 2 A kind of tilmicosin premix and preparation method thereof

[0045] The composition comprises the following components in parts by weight: 25 parts of tilmicosin, 15 parts of flavoring agent, 35 parts of microcrystalline cellulose sodium, 35 parts of corn starch, 150 ppm of food attractant and 12 parts of acrylic resin.

[0046] The attractant is L-alanine, L-aspartic acid and betaine with a mass ratio of 5:2:1.

[0047] The preparation method of described tilmicosin premix comprises the following steps:

[0048] (1) After mixing the flavoring agent, microcrystalline cellulose sodium, cornstarch and tilmicosin, add an appropriate amount of water and stir to obtain a uniform wet material;

[0049] (2) The wet material obtained in the step (1) is extruded and rounded to obtain a tilmicosin wet pellet core;

[0050] (3) Coating, sizing, and drying the tilmicosin wet pellet core obtained in step (2) using a mixed solution of 8% acrylic resin and an attractant...

Embodiment 3

[0051] Embodiment 3 a kind of tilmicosin premix and preparation method thereof

[0052]Comprising the following components in parts by weight: 18 parts of tilmicosin, 8 parts of flavoring agent, 20 parts of microcrystalline cellulose sodium, 15 parts of cornstarch, 50 ppm of food attractant, 1 part of reinforcing agent and 10 parts of acrylic resin share.

[0053] The attractant is L-alanine, L-aspartic acid and betaine with a mass ratio of 2:2:1;

[0054] The enhancer is pullulan, alginic acid and chitooligosaccharide with a mass ratio of 1:1:1;

[0055] The preparation method of described tilmicosin premix comprises the following steps:

[0056] (1) After mixing the flavoring agent, reinforcing agent, microcrystalline cellulose sodium, cornstarch and tilmicosin, add an appropriate amount of water and stir to obtain a uniform wet material;

[0057] (2) The wet material obtained in the step (1) is extruded and rounded to obtain a tilmicosin wet pellet core;

[0058] (3) Co...

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Abstract

The invention provides a tilmicosin premix and a preparation method thereof, belonging to the technical field of veterinary medicine. Described tilmicosin premix comprises the following components in parts by weight: tilmicosin, flavoring agent, microcrystalline cellulose sodium, cornstarch and food attractant; Adding microcrystalline cellulose and cornstarch with a mass ratio of 1‑3:1 as a carrier obviously improves the stability of the premixed agent obtained and can improve bioavailability; with a mass ratio of 2‑5:2:1 L‑ Alanine, L-aspartic acid and betaine are feed attractants, not only cover bad smell and irritation, but also effectively ensure the feed intake of sick animals to medicine; the present invention also adds enhancer, and control the mass ratio of tilmicosin to enhancer to 10‑20:1, which not only improves the dissolution stability of the premix in gastric juice to a certain extent, but also improves the long-term storage of the premix stability.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a tilmicosin premix and a preparation method thereof. Background technique [0002] As a major discovery in the development of human science and technology, antibiotics are a milestone in the fields of biology and medicine. Since the advent of penicillin in 1940, various synthetic and semi-synthetic antibiotics have emerged one after another, becoming an important weapon to protect the health of humans, animals and plants. The research and application of antibiotics are becoming more and more extensive, and they have played an important role in the prevention and control of animal diseases, improving feed utilization, and promoting the growth of livestock and poultry. [0003] Tilmicosin is a semi-synthesized macrolide antibiotic for livestock and poultry with tylosin as the precursor. Tilmicosin has a good inhibitory effect on gram-positive bacteria and some gram-n...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/32A61K31/706A61K47/38A61K47/36A61K47/18A61P31/04
CPCA61K9/2054A61K9/2059A61K9/282A61K9/284A61K9/286A61K31/706A61P31/04
Inventor 高平陈振威李云梁金兰刘为和
Owner GUANGZHOU HESHENGTANG ANIMAL PHARMA
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