A kind of three-dimensional printing composite aerogel to construct a simulated gas pipe and its preparation method

A composite aerogel, three-dimensional printing technology, applied in tissue regeneration, pharmaceutical formulations, prostheses, etc., can solve problems such as high cost and cumbersome processing methods, and achieve simple technology, good repeatability, and excellent personalized customization performance. Effect

Active Publication Date: 2022-07-08
DONGHUA UNIV
View PDF19 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a three-dimensional printing composite aerogel to construct an imitation air tube and its preparation method, which overcomes the limitations of the prior art in using the organism's own tissue to extract materials, and the defects of cumbersome processing methods and high cost

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of three-dimensional printing composite aerogel to construct a simulated gas pipe and its preparation method
  • A kind of three-dimensional printing composite aerogel to construct a simulated gas pipe and its preparation method
  • A kind of three-dimensional printing composite aerogel to construct a simulated gas pipe and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] (1) Prepare polylactic acid (molecular weight 300000, Guangzhou Maipu Regenerative Medicine Co., Ltd.) / gelatin (Beijing Innochem, innochem, B76801) spinning solution: mix 0.2g gelatin and 0.8g polylactic acid (mass ratio is 1:4 ) was dissolved in 10 mL of hexafluoroisopropanol (>99%, Shanghai Darui Chemical Co., Ltd.) with a mass fraction of 10%.

[0055] (2) Preparation of biological nanofiber membrane by electrospinning: suck the polylactic acid / gelatin spinning solution into the syringe, control the advancing rate of the micro-injection pump to 2.0mL / h, connect the 12.5KV high-voltage power supply to the needle of the syringe, and receive it with aluminum foil , the receiving distance was 13 cm, and the gelatin / polylactic acid nanofiber membrane was obtained by electrospinning. The nanofiber membrane needs to be vacuum dried for 24h under the condition of vacuum degree of -25KPa and drying temperature of 25℃.

[0056] (3) Homogenization and pulverization of the biol...

Embodiment 2

[0071] (1) Prepare polylactic acid (molecular weight 300000, Guangzhou Maipu Regenerative Medicine Co., Ltd.) / gelatin (Beijing Innochem, innochem, B76801) spinning solution: mix 0.2g gelatin and 0.8g polylactic acid (mass ratio is 1:4 ) was dissolved in 10 mL of hexafluoroisopropanol (>99%, Shanghai Darui Chemical Co., Ltd.) with a mass fraction of 10%.

[0072] (2) Preparation of biological nanofiber membrane by electrospinning: suck the polylactic acid / gelatin spinning solution into the syringe, control the advancing rate of the micro-injection pump to 2.0mL / h, connect the 12.5KV high-voltage power supply to the needle of the syringe, and receive it with aluminum foil , the receiving distance was 13 cm, and the gelatin / polylactic acid nanofiber membrane was obtained by electrospinning. The nanofiber membrane needs to be vacuum dried for 24h under the condition of vacuum degree of -25KPa and drying temperature of 25℃.

[0073] (3) Homogenization and pulverization of the biol...

Embodiment 3

[0090] (1) Prepare polylactic acid (molecular weight 300000, Guangzhou Maipu Regenerative Medicine Co., Ltd.) / gelatin (Beijing Innochem, innochem, B76801) spinning solution: mix 0.2g gelatin and 0.8g polylactic acid (mass ratio is 1:4 ) was dissolved in 10 mL of hexafluoroisopropanol (>99%, Shanghai Darui Chemical Co., Ltd.) with a mass fraction of 10%.

[0091] (2) Preparation of biological nanofiber membrane by electrospinning: suck the polylactic acid / gelatin spinning solution into the syringe, control the advancing rate of the micro-injection pump to 2.0mL / h, connect the 12.5KV high-voltage power supply to the needle of the syringe, and receive it with aluminum foil , the receiving distance was 13 cm, and the gelatin / polylactic acid nanofiber membrane was obtained by electrospinning. The nanofiber membrane needs to be vacuum dried for 24h under the condition of vacuum degree of -25KPa and drying temperature of 25℃.

[0092] (3) Homogenization and pulverization of the biol...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
softening pointaaaaaaaaaa
distanceaaaaaaaaaa
Login to view more

Abstract

The invention relates to a three-dimensional printing composite aerogel to construct a simulated gas pipe and a preparation method thereof. The polylactic acid / gelatin aerogel of the present invention has a nanofiber structure, and is a porous, extrudable, sponge structure material with excellent water absorption. The material obtained by the invention can promote the formation of chondrocyte matrix, and provide effective support for the long-term stability of the function of the simulated trachea.

Description

technical field [0001] The invention belongs to the field of artificial gas pipes and preparation thereof, and particularly relates to a three-dimensional printing composite aerogel to construct a simulated gas pipe and a preparation method thereof. Background technique [0002] The trachea is a vascularized hollow tube that connects the larynx and the lungs. A variety of diseases can cause tracheal stenosis, affect ventilation function, and even cause suffocation in severe cases, which is life-threatening. Currently, the gold standard treatment is to restore the continuity of the trachea using tracheectomy, i.e. tracheectomy followed by reconstruction of the tracheal anastomosis. Other treatments include tracheal stenting or sliding tracheoplasty. All of the above treatments have had varying degrees of success, but there are no clinically feasible options for patients with long-segment airway disorders. For adults with tracheal stenosis and defect length less than 6 cm, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61L27/22A61L27/50A61L27/52A61L27/56B33Y10/00B33Y70/10B33Y80/00
CPCA61L27/18A61L27/222A61L27/50A61L27/52A61L27/56B33Y10/00B33Y70/10B33Y80/00A61L2430/22A61L2400/12C08L67/04
Inventor 莫秀梅袁征超沈威陈玉杰
Owner DONGHUA UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap