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Driving method for liquid flow of micro-fluidic chip

A technology of microfluidic chips and driving methods, applied in fluid controllers, chemical instruments and methods, and laboratory containers, etc., can solve difficult and unrealistic problems in mass production, achieve rapid mass production, and reduce production difficulty Effect

Pending Publication Date: 2021-06-08
HARBIN MEDICAL UNIVERSITY +1
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  • Application Information

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Problems solved by technology

[0003] However, if the outlets are arranged in the same way as the outlets of the main channel, in order to avoid the mutual interference of the branch channels, it is necessary to arrange a large number of branch channel outlets, which is obviously unrealistic
[0004] At present, because PDMS has a certain degree of air permeability, many chips use PDMS as the main body of microfluidic chips to avoid the above problems. However, because PDMS is only suitable for laboratory production and is difficult to produce in large quantities, we have proposed a new technical solution. Realize the driving of liquid in the branch of microfluidic chip

Method used

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Embodiment Construction

[0026] Such as Figure 1 to Figure 4 As shown, in a microfluidic chip for detection in the embodiment, the liquid flows from the liquid inlet 11 through the main channel 12 to the outlet 15 at the end of the main channel. In order to make the channel branch 13 and the branch well 14 is filled with liquid, the main channel 12 and flow channel branch 13 of the main chip 1 are open, covered by the isolation film 3, the entire main chip 1 is a closed chip, except for the escape port In addition, since the isolation membrane 3 is air-permeable and impermeable, the isolation membrane 3 is above the main channel 12, the flow channel branch 13 and the branch well 14, so the liquid is also sealed in the main chip 1. Above, the negative pressure channel 21 on the upper plate 2 communicates with the area of ​​the isolation membrane 3 above the branch wells 14, so that after the liquid enters the channel branch 13, it will The pressure makes the inspection fluid in the main channel 12 fi...

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Abstract

The invention relates to a driving method for liquid flow of a micro-fluidic chip, the driving method is characterized in that in the process that liquid dispersedly flows from the main flow channel of a main chip to branches, the positions of branch wells are communicated with a negative pressure flow channel through isolating membranes, and the negative pressure flow channel is communicated with all or part of the branch wells through isolating membranes according to needs, different negative pressures are applied to the negative pressure flow channel or thrust is generated in the main flow channel according to needs so that the speed of the main flow channel entering the flow channel branch and the branch well is controlled.

Description

technical field [0001] The invention relates to a method for driving liquid flow in a microfluidic chip. Background technique [0002] The driving mode of the liquid flow in the microfluidic chip is mainly thrust or suction; in the flow channel of the microfluidic chip, there are only main channels, or when there are few main channels, the main channels are arranged with outlets, which does not affect the production and use, but when When there is a branch flow channel, when the branch does not flow out to the main channel, it is difficult for the liquid to flow to the branch flow channel and fill the branch well at the branch end of the flow channel. Gas, which can only enter when the gas is expelled; [0003] However, if the outlets are arranged in the same way as the outlets of the main channel, in order to avoid mutual interference of the branch channels, a large number of outlets of the branch channels need to be arranged, which is obviously unrealistic. [0004] At p...

Claims

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Application Information

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IPC IPC(8): B01L3/00
CPCB01L3/50273B01L3/5027B01L2400/0487B01L2400/049
Inventor 张显玉顾宇灵庞达
Owner HARBIN MEDICAL UNIVERSITY
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