Laser biological tissue welding and suturing method with energy targeted regulation

A technology of biological tissue and target biological tissue, which is applied in parts of surgical instruments, medical science, surgery, etc., can solve the problems of inability to guarantee welding quality, promotion of clinical application, limited effect of forming improvement, and reduction of tensile strength of joints, etc., to achieve Rapid hemostasis suture function, reduced psychological burden, instant watertight effect

Active Publication Date: 2021-06-15
NANJING UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of controlling the formation of biological tissue welding by simply changing the energy parameters is very limited, and a single laser energy cannot form full-layer penetration without causing a large amount of thermal damage to the surface tissue, resulting in a decrease in the tensile strength of the joint. It is easy to crack after welding, and the technology that cannot guarantee the welding quality cannot be promoted in clinical application

Method used

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  • Laser biological tissue welding and suturing method with energy targeted regulation
  • Laser biological tissue welding and suturing method with energy targeted regulation
  • Laser biological tissue welding and suturing method with energy targeted regulation

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Experimental program
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Effect test

Embodiment 1

[0033] Using the above-mentioned device, adopt the method of laser bio-tissue welding seam tracking to weld isolated pig skin tissue, select pig skin as the sample, its size is 30mm×30mm×4mm, it is composed of epidermis and dermis, and contains 0.5mm thick Subcutaneous fat layer, incision shape is straight line. The corresponding laser welding process parameters of pigskin are shown in Table 1.

[0034] Table 1 Pigskin laser welding process parameters

[0035] wavelength / nm Power / W Spot diameter / μm Welding speed mm / s Welding time / s 1064 4 35.5 100 400

[0036] The laser biological tissue welding and suturing method with targeted energy regulation is used for incision welding, and the flux is applied to automatically match the appropriate welding process parameters. By controlling the parameter matching of the laser process, different kinds of biological tissues can be welded. The temperature data is collected by a thermal imager. If the tempera...

Embodiment 2

[0044] Using the above device, the skin tissue of living rats is welded by laser biological tissue welding seam tracking method. The incision is on the back of the rat, which has spatial bending and irregular curves, and is welded with suitable process parameters.

[0045] Using a laser biological tissue welding and suturing method for energy targeting regulation according to the present invention, the specific steps are:

[0046] Step 1, inject 350 mg of 10% chloral hydrate solution intraperitoneally into 200 g heavy SD rats, remove the hair on the back of the rat after the anesthesia takes effect in 3-5 minutes, and clean up a 30 mm × 30 mm area to expose the skin for easy operation;

[0047] Step 2, transfer the rat to the ultra-clean workbench, cut a 10mm long, 2mm deep incision in the depilatory area with a scalpel, and disinfect it with medical alcohol; inject indocyanine green dyeing flux into the incision endothelial 1mm, the concentration is 2.5mg / mL, fill the bottom ...

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Abstract

The invention relates to a laser biological tissue welding and suturing method with energy targeted regulation. The laser biological tissue welding and suturing method comprises the following steps: measuring an absorption coefficient of a biological tissue to laser and a penetration depth of the laser in the tissue through a laser generator and an optical signal sensor; treating the biological tissue, and performing dyeing at a proper depth with a stain which is a mixture of indocyanine green and chitosan and has good biocompatibility and competitive absorption to laser; and applying the prepared stain at the preset depth to fill a welding joint with the stain, applying lateral pressure to attach the stain to the welding joint with a clamp, reserving a gap of 0.2-0.3mm to enable laser to pass through so as to scan and weld the welding joint. By utilizing the method, the biological tissue can be welded, slot weld of biological tissues at various thicknesses can be subjected to all-thickness welding. The method is applicable to welding and suturing of skin tissues and muscle tissues, the weld joint suturing has strong adaptability, operation is convenient, short time is consumed, toxicity or rejection does not exist, and the suturing strength is high. The method can accelerate the recovery speed for surgical incision.

Description

technical field [0001] The invention belongs to the field of laser surgery, in particular to a laser biotissue welding and suturing method for targeted regulation of energy. Background technique [0002] In clinical operations, one of the most common wound treatment methods is needle and thread suture. Needle and thread suture technology is a fast and direct wound closure operation, which has an irreplaceable role in some occasions. However, needle and thread suture surgery also has limitations in its use. First of all, although the sutures used in the operation can be divided into absorbable sutures and non-absorbable sutures, any suture is a foreign object to the human body. As a contact wound healing method, the sutures left in the body will cause adverse reactions to the human body. If it is mild, it will cause local discomfort, and if it is severe, it will cause inflammation such as redness, swelling and pain, which will affect the speed of wound healing. Furthermore,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B18/20
CPCA61B18/20A61B2018/00619
Inventor 王克鸿李聪张明朗夏浩
Owner NANJING UNIV OF SCI & TECH
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