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Recombinant rsv live vaccine strain and production method therefor

A technology of syncytial virus and respiratory tract, applied in the field of RSV live vaccine strain and preparation thereof, can solve problems such as difficulty in preparation and purification, difficulty in maintaining stability and effectiveness, etc.

Inactive Publication Date: 2021-06-15
SK BIOSCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, F protein antigen is a stable form of pre-fusion (pre-fusion) protein, so it is difficult to prepare and purify, and it is difficult to maintain its stability and effectiveness

Method used

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  • Recombinant rsv live vaccine strain and production method therefor
  • Recombinant rsv live vaccine strain and production method therefor
  • Recombinant rsv live vaccine strain and production method therefor

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Embodiment Construction

[0078] Hereinafter, this patent is described in detail through examples and the like to help understanding of the present invention. However, the embodiments according to the present invention may be changed into various other forms, and it should not be construed that the scope of the present invention is limited by the following examples. The examples of the present invention are provided so as to more fully describe the invention to those with average knowledge in the art.

[0079] 1. Preparation of wild-type RSV-A virus strain

[0080] A wild-type RSV A strain was prepared with the following information.

[0081] - Definition: Human respiratory syncytial virus strain RSVA / TH_10654 / whole genome

[0082] -Accession No.: KU950464.1

[0083] - Length: 15232bp

[0084] -Host: Homo sapiens / female / 12 weeks

[0085] - Collection date: February 19, 2014

[0086] -Country: USA

[0087] - Subtype: RSV A

[0088] The strain is represented by SEQ ID NO.1.

[0089] 2. Preparati...

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Abstract

The present invention provides a gene recombinant respiratory syncytial virus (RSV) in which genes encoding the envelope proteins of an RSV are rearranged, wherein in the RSV, a gene encoding the fusion protein (F protein) derived from a heterologous virus belonging to the family Paramyxoviridae or the family Pneumoviridae is inserted between the genes respectively encoding the glycoprotein (G protein) and the F protein of the RSV, or the gene encoding the F protein of the RSV is substituted with a gene encoding the F protein of a heterologous virus belonging to the family Paramyxoviridae or the family Pneumoviridae. The recombinant RSV of the present invention can be used as an RSV vaccine strain, and can be used as a vaccine due to having excellent stability and safety.

Description

technical field [0001] This application claims the priority of Korean Patent Application No. 10-2018-0122162 filed on October 12, 2018, and all the contents disclosed in the specification and drawings of the corresponding application are hereby incorporated by reference into this application. The invention relates to a live RSV vaccine strain and a preparation method thereof. More specifically, the present invention relates to live recombinant RSV vaccines and methods for their preparation. Background technique [0002] Respiratory syncytial virus (RSV) is a very common infectious virus worldwide that causes respiratory disease. In particular, it is a leading cause of death in infants due to severe respiratory infections. While infants are at the highest risk of infection, it can also cause fatal respiratory disease in immunocompromised patients and the elderly by causing respiratory infections. Although it is the second leading cause of respiratory disease after influenz...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N7/00C07K14/005A61K39/155A61K39/295A61P31/14A61K39/00
CPCA61P31/14C07K14/005C12N7/00A61K39/12C12N2760/18534A61K39/155A61K39/295A61K2039/5254C12N2760/18134C12N2760/18434C12N2760/18522C12N2760/18422C12N2760/18122A61K39/165A61K39/17A61K2039/70C12N15/86C12N2760/18171C12N2760/18471C12N2760/18521C12N2760/18543C12N2760/18551C12N2760/18562C12N2760/18571
Inventor 徐基元金恩顺权泰佑洪承惠金勋李受陈
Owner SK BIOSCI CO LTD
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