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Silver-containing hydrogel as well as preparation method and application thereof

A technology of gel and silver water, which is applied in the field of biomedical engineering materials, can solve problems such as unsatisfactory effects, and achieve the effects of shortening the wound healing period, slow and efficient release, excellent mechanical properties and antibacterial properties

Active Publication Date: 2021-06-18
广州信筑医疗技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional treatment methods for chronic refractory wounds include wound cleaning and dressing, local or systemic application of antibiotics, various physical therapies, skin grafting or flap transplantation when the wound surface permits, etc., but the effect is not satisfactory

Method used

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  • Silver-containing hydrogel as well as preparation method and application thereof
  • Silver-containing hydrogel as well as preparation method and application thereof
  • Silver-containing hydrogel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The preparation of oxidized dextran (ODEX) comprises the steps:

[0039] (1) Add 1.0 g of dextran (DEX) into 40 mL of deionized water to dissolve it completely to obtain a dextran solution;

[0040] (2) 0.54g of sodium periodate was added into 10mL of deionized water to dissolve it completely to obtain a sodium periodate solution;

[0041] (3) Slowly add the sodium periodate solution obtained in step (2) to the dextran solution obtained in step (1), and react with magnetic stirring for 5 to 7 hours under dark conditions at 25°C. Alcohol, magnetically stirred for 15-20 hours to remove unreacted sodium periodate;

[0042] (4) Put the reaction system of step (3) into a dialysis bag with a molecular weight cut-off of 3500D, perform dialysis in deionized water, change the water once every 6 hours, and freeze-dry after 3 days of dialysis to obtain ODEX.

Embodiment 2

[0044] The preparation of hydrogel comprises the following steps:

[0045] (1) ethylene glycol chitosan is dissolved in PBS damping fluid, and the obtained mass fraction is 4.5% ethylene glycol chitosan solution;

[0046] (2) Dissolving the oxidized dextran prepared in Example 1 in water to prepare oxidized dextran solutions with mass fractions of 10%, 15% and 20% respectively;

[0047] (3) The ethylene glycol chitosan solution obtained by step (1) is mixed with the oxidized dextran solution of each concentration obtained by step (2) respectively by a volume ratio of 1:1, and left to stand for 3min, freeze-dried, Obtain a hydrogel; wherein, the hydrogel obtained by the ODEX solution with a mass fraction of 10% is denoted as "GCS / ODEX (10%)", and the hydrogel obtained by the ODEX solution with a mass fraction of 15% is denoted as " GCS / ODEX (15%)", and the hydrogel obtained with a 20% mass fraction of ODEX solution is recorded as "GCS / ODEX (20%)".

Embodiment 3

[0049] The preparation of silver-containing hydrogel (referred to as GCS / ODEX-AgNPs) comprises the following steps:

[0050] (1) ethylene glycol chitosan is dissolved in the PBS damping fluid, and the obtained mass fraction is 4.5% ethylene glycol chitosan solution;

[0051] (2) Under magnetic stirring, 5.5 mg of silver nitrate was dissolved in 100 mL of deionized water, then 0.5 g of dextran was added to form a stable colloidal solution, and 10 mL of trisodium citrate solution with a mass fraction of 3% was added dropwise. A light yellow nano-silver colloid solution with a concentration of 50 μg / mL was prepared;

[0052] (3) Dissolving the oxidized dextran prepared in Example 1 in water to prepare an oxidized dextran solution with a mass fraction of 20%;

[0053] (4) Mix the ethylene glycol chitosan solution obtained by step (1) with the nano-silver colloid solution obtained by step (2), then add the oxidized dextran solution obtained by step (3) and stir, leave standstill for...

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Abstract

The invention discloses a preparation method of silver-containing hydrogel. The method comprises the following steps: dissolving ethylene glycol chitosan in a solvent to prepare an ethylene glycol chitosan solution; dissolving silver nitrate in water, then adding glucan to form a stable colloidal solution, and dropwise adding a trisodium citrate solution to prepare a nano-silver colloidal solution; dissolving oxidized dextran in water to prepare an oxidized dextran solution; and uniformly mixing an ethylene glycol chitosan solution with a nano-silver colloidal solution, then adding an oxidized dextran solution to carry out Schiff base reaction, and freeze-drying to obtain the silver-containing hydrogel. The hydrogel disclosed by the invention has a uniform porous net structure, shows excellent mechanical property and antibacterial property, slowly releases silver ions, can also load medicines such as deferrimine and the like, ensures that the medicines are slowly and efficiently released, promotes revascularization, shortens a wound healing period, and has a relatively good treatment effect on refractory wounds.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering materials, and in particular relates to a silver-containing hydrogel and a preparation method and application thereof. Background technique [0002] Clinically, chronic refractory wounds refer to wounds caused by various reasons that have not healed and have no tendency to heal after formal treatment for more than one month. This kind of wound cannot repair itself according to the normal and orderly mechanism, but becomes a state of pathological inflammatory response, which cannot achieve completeness in anatomy and function. Chronic refractory wounds mainly include diabetic ulcers, trauma, pressure ulcers (decubitus ulcers), arteriovenous ulcers, radiation ulcers, malignant tumors, and infectious ulcers. [0003] The high disability rate and mortality rate of chronic refractory wounds not only bring physical and mental pain to patients and their families, but also cause huge econo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L5/02C08L5/08C08K3/08A61L26/00
CPCA61L26/0004A61L26/0023A61L26/0066A61L26/008A61L26/0085A61L2300/104A61L2300/404A61L2300/602C08J3/075C08J3/246C08J2305/02C08J2305/08C08J2405/02C08J2405/08C08K2003/0806C08L5/08C08L5/02
Inventor 牛晓兵
Owner 广州信筑医疗技术有限公司
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