Silver-containing hydrogel as well as preparation method and application thereof

A technology of gel and silver water, which is applied in the field of biomedical engineering materials, can solve problems such as unsatisfactory effects, and achieve the effects of shortening the wound healing period, slow and efficient release, excellent mechanical properties and antibacterial properties
CN112979995AActive Publication Date: 2021-06-18广州信筑医疗技术有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
广州信筑医疗技术有限公司
Publication Date
2021-06-18

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Abstract

The invention discloses a preparation method of silver-containing hydrogel. The method comprises the following steps: dissolving ethylene glycol chitosan in a solvent to prepare an ethylene glycol chitosan solution; dissolving silver nitrate in water, then adding glucan to form a stable colloidal solution, and dropwise adding a trisodium citrate solution to prepare a nano-silver colloidal solution; dissolving oxidized dextran in water to prepare an oxidized dextran solution; and uniformly mixing an ethylene glycol chitosan solution with a nano-silver colloidal solution, then adding an oxidized dextran solution to carry out Schiff base reaction, and freeze-drying to obtain the silver-containing hydrogel. The hydrogel disclosed by the invention has a uniform porous net structure, shows excellent mechanical property and antibacterial property, slowly releases silver ions, can also load medicines such as deferrimine and the like, ensures that the medicines are slowly and efficiently released, promotes revascularization, shortens a wound healing period, and has a relatively good treatment effect on refractory wounds.
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Description

technical field

[0001] The invention belongs to the technical field of biomedical engineering materials, and in particular relates to a silver-containing hydrogel and a preparation method and application thereof. Background technique

[0002] Clinically, chronic refractory wounds refer to wounds caused by various reasons that have not healed and have no tendency to heal after formal treatment for more than one month. This kind of wound cannot repair itself according to the normal and orderly mechanism, but becomes a state of pathological inflammatory response, which cannot achieve completeness in anatomy and function. Chronic refractory wounds mainly include diabetic ulcers, trauma, pressure ulcers (decubitus ulcers), arteriovenous ulcers, radiation ulcers, malignant tumors, and infectious ulcers.

[0003] The high disability rate and mortality rate of chronic refractory wounds not only bring physical and mental pain to patients and their families, but also cause huge econo...

Claims

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