General automatic metabolite collecting device for rats and mice

Abstract

The invention provides a general automatic metabolite collecting device for rats and mice. The general automatic metabolite collecting device comprises a metabolism unit and a collecting unit, and the metabolism unit comprises a rearing cage and an excrement and urine separator. The collection unit comprises a preservation box, a collection disc, a control assembly, a detection assembly and a purging assembly. The collection disc and the control assembly are both arranged inside the preservation box, a plurality of urine collection test tubes are arranged on the collection disc, and the control assembly can drive the collection disc to switch the urine collection test tubes. The detection assembly comprises a drinking water detector and a urine collection detector, drinking water information can be detected through the drinking water detector, urine collection information can be detected through the urine collection detector, and the purging assembly can conduct adaptive purging on the excrement and urine separator according to the difference value of the drinking water amount information and the urine collection amount information before the urine collection test tubes switching action is conducted on the collection disc. According to the general automatic metabolite collecting device for the rats and mice, the automation degree of laboratory mouse metabolite collection can be improved, and the sample collection precision is improved.

Description

technical field [0001] The invention belongs to the field of experimental equipment, and in particular relates to a universal automatic metabolite collection device for rats and mice. Background technique [0002] In the prior art, due to the advantages of good biological stability, easy replication of disease models and low experimental cost, experimental mice are widely used in the research process of physiology, pharmacology and metabolic diseases. When conducting research, researchers need to raise experimental mice in metabolic cages, monitor the food intake, water intake and excretion of experimental mice, and collect and analyze their metabolites, so as to analyze the metabolism of drugs or nutrients in animals. Situation research. [0003] However, the existing metabolic cages for experimental mice generally have the problem of low degree of automation. Due to the low degree of automation of metabolic cages, when it is necessary to collect metabolite samples at mul...

AI Technical Summary

Problems solved by technology

This will not only consume a lot of time and cost, but also affect the living conditions of experimental mice due to frequent manual intervention, thereby reducing the accuracy of metabolic experiment results

[0004] In addition, the existing metabolic cages still have the problem of low sample collection accuracy in the urine collection of experimental mice

Because the urine of the experimental mice will inevitably remain in the metabolic cage, the volume of urine collected in the experiment often has errors from the actual results

Especially when using small experimental mice for experiments, because the urine volume of mice is small, the residual urine will amplify the influence of collection errors, resulting in inaccurate experimental results

Secondly, during the continuous collection of multiple samples, the residual urine in the metabolic cage will also pollute subsequent samples

After being contaminated, the composition of the sample will change, which will lead to errors in the analysis results, which will further affect the accuracy of the metabolism experiment

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