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Application of β-cyclodextrin derivative compounds in the preparation of drugs or preparations for promoting wound healing

A wound healing and compound technology, applied in the directions of drug combinations, antipyretics, anti-inflammatory agents, etc., can solve the problems of high price, difficult delivery of cytokines, side effects, etc., and achieve the effect of good biocompatibility

Active Publication Date: 2022-06-21
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In general, the cytokines interleukin 4 (IL-4) and interleukin 13 (IL-13) are required to induce M2 polarization of macrophages, however, cytokine delivery is difficult, easily degraded, expensive, and excessive use can cause severe Side effects (Biomaterials, 2019, 219:119340)

Method used

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  • Application of β-cyclodextrin derivative compounds in the preparation of drugs or preparations for promoting wound healing
  • Application of β-cyclodextrin derivative compounds in the preparation of drugs or preparations for promoting wound healing
  • Application of β-cyclodextrin derivative compounds in the preparation of drugs or preparations for promoting wound healing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Synthesis of CD-Man7

[0038] 6-hydroxyazide-substituted β-cyclodextrin (β-CD-N 3 ) The synthetic route can be referred to the literature (Journal of Organic Chemistry, 1996, 61:903-908). 0.5g β-CD-N 3 with 0.7g propargyl-α-D-mannopyranoside It was dissolved in 2.5 mL of DMF solution, and then 2.5 mL of aqueous solution containing 100 mg of copper sulfate pentahydrate and 160 mg of sodium ascorbate was added dropwise, and the reaction solution was stirred at 60° C. for 48 hours under nitrogen protection. The reaction solution was filtered with a 0.45 μm membrane, dialyzed and lyophilized, and separated by a gel column to obtain CD-Man7.

Embodiment 2

[0039] Example 2C 3 - Synthesis of CD-Man7

[0040] 0.75g β-CD-N 3 It was dissolved in 18 mL of anhydrous pyridine with 2.25 g of 4-dimethylaminopyridine, and 5 mL of propionic anhydride was added to the reaction solution, followed by stirring at 60° C. for 48 hours under nitrogen protection. After the reaction was completed, dialyzed and lyophilized to obtain C through silica gel column separation. 3 -CD-N 3 . will C 3 -CD-N 3 Instead of β-CD-N in Example 1 3 , by click chemistry with 0.7g reaction to make C 3 - CD-Man7. For specific experimental methods, please refer to the literature (Chemistry-A European Journal, 2016, 22:15216-15221).

Embodiment 3

[0041] Example 3C 2 - Synthesis of CD-Man7

[0042] Substituting acetic anhydride for propionic anhydride in Example 2, and performing the same operation, an amphiphilic β-cyclodextrin compound (C 2 -CD-Man7).

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Abstract

The invention relates to the application of a β-cyclodextrin derivative compound in the preparation of wound healing-promoting medicine or preparation. The present invention utilizes abundant β-cyclodextrin as a raw material, introduces multiple sugar ligand molecules on the primary hydroxyl surface of β-cyclodextrin, and introduces fatty chains into its secondary hydroxyl surface as a hydrophobic part, through mannose Coupling modified β-cyclodextrin molecules to prepare mannose-modified β-cyclodextrin compounds and sugar nanoparticles with polyvalent effects of sugar ligands. The use of this mannose-modified β-cyclodextrin compound can stimulate the polarization of macrophages at the wound site into the M2 type, thereby promoting tissue repair and wound healing. The mannose-modified β-cyclodextrin compound of the invention not only has low toxicity, but also has the function of promoting tissue repair and wound healing, and can be used as a medicine or a medicament.

Description

technical field [0001] The invention relates to the application of a beta-cyclodextrin derivative compound in the preparation of a medicine or preparation for promoting wound healing, and belongs to the field of medicine and pharmacy. Background technique [0002] Wound healing treatment has always been an issue of great concern in the field of healthcare and clinical medicine, which brings huge human, material and financial burdens to people every year (Physiological Reviews, 2019, 99(1): 665-706). Drugs currently used in wound healing, such as growth factor gels, can accelerate wound healing by promoting cell proliferation, skin and angiogenesis. However, growth factors are expensive and difficult to store, limiting their large-scale use. Yunnan Baiyao powder has the functions of removing blood stasis and hemostasis, promoting blood circulation and relieving pain, detoxifying and reducing swelling, but it has no obvious effect on promoting wound healing for large-area wou...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/724A61P17/02A61P29/00C08B37/16
CPCA61K31/724A61P17/02A61P29/00C08B37/0012
Inventor 张权孔祥东张远宁赵瑞波罗丹丹
Owner ZHEJIANG SCI-TECH UNIV
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