Hydrophilic lubricating coating for the surface of a medical catheter

A medical catheter and hydrophilic technology, applied in the direction of catheters, coatings, etc., can solve the problems of uniform coating of unfavorable hydrophilic polymers, lower solubility, lower lubricity and wettability of medical catheters, etc., to achieve Improve the uniformity of spreading, improve fluidity, and have strong reactivity

Active Publication Date: 2022-04-15
SHENZHEN XUANLI PLASTIC SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the molecular weight of the hydrophilic polymer is too large, the solubility in water is reduced, and it is not conducive to the uniform coating of the hydrophilic polymer on the surface of the medical catheter substrate, thereby reducing the lubrication of the medical catheter after wetting. sex and wettability

Method used

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  • Hydrophilic lubricating coating for the surface of a medical catheter
  • Hydrophilic lubricating coating for the surface of a medical catheter
  • Hydrophilic lubricating coating for the surface of a medical catheter

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Embodiments 1-18 provide a hydrophilic lubricating coating for the surface of a medical catheter, which will be described below by taking Embodiment 1 as an example.

[0032] The hydrophilic lubricating coating for the surface of the medical catheter provided by embodiment 1, its preparation steps are:

[0033] First mix 200g polyvinylpyrrolidone, 100g polyvinyl alcohol, 50g hydroxyethyl starch, 50g cross-linked polyacrylic acid resin, 400g solvent, stir evenly, then add 100g polyethyleneimine and 100g maleic anhydride grafted SEBS, mix, Stir evenly to obtain a hydrophilic lubricating coating for the surface of the medical catheter;

[0034] Wherein, the polyvinylpyrrolidone is PVP-K110, the number average molecular weight is 1.0993 million, purchased from Gobekie Company; the polyvinyl alcohol is PVA-124, the average degree of polymerization is 2400-2500, and the degree of alcoholysis is 98-99mol% , purchased from Kuraray, Japan;

[0035] The hydroxyethyl starch is h...

Embodiment 2-5

[0040] Examples 2-5 differ from Example 1 only in that the quality of the raw materials for the preparation of the hydrophilic lubricating coating for the surface of the medical catheter is different, see Table 1 for details.

[0041] Prepare raw materials Example 1 Example 2 Example 3 Example 4 Example 5 Polyvinylpyrrolidone 200g 400g 300g 300g 300g polyvinyl alcohol 100g 200g 150g 150g 150g Hydroxyethyl starch 50g 150g 100g 50g 100g Cross-linked polyacrylic resin 50g 150g 100g 50g 100g solvent 400g 600g 500g 500g 500g Polyethyleneimine 100g 200g 150g 150g 100g Maleic anhydride grafted SEBS 100g 200g 150g 150g 100g

Embodiment 6-8

[0042] Examples 6-8 differ from Example 3 only in that the solvents are different, see Table 2 for details.

[0043] Example solvent Example 3 Water, isopropanol and triethylamine are mixed at a mass ratio of 5:1:0.01 Example 6 Water, isopropanol and triethylamine are mixed at a mass ratio of 8:1:0.02 Example 7 Water, isopropanol and triethylamine are mixed at a mass ratio of 6:1:0.015 Example 8 Water and isopropanol are mixed at a mass ratio of 5:1

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Abstract

The application belongs to the field of medical catheters, in particular to a hydrophilic lubricating coating for the surface of medical catheters. In parts by weight, the raw materials for the preparation of the hydrophilic lubricating coating on the surface of the medical catheter include 20-40 parts of polyvinylpyrrolidone, 10-20 parts of polyvinyl alcohol, 10-20 parts of polyethyleneimine, and 5-15 parts of hydroxyethyl starch , 5-15 parts of cross-linked polyacrylic resin, 10-20 parts of maleic anhydride grafted SEBS and 40-60 parts of solvent; the number average molecular weight of the polyvinylpyrrolidone is 100-1.76 million; the average polyvinyl alcohol The degree of polymerization is 2400-2500, and the degree of alcoholysis is 98-99mol%. The hydrophilic lubricating coating for the surface of the medical catheter provided by the application has good bonding performance to the base material of the medical catheter, and the hydrophilic lubricating coating has good fluidity, which improves the lubricity of the medical catheter after wetting.

Description

technical field [0001] The application belongs to the field of medical catheters, in particular to a hydrophilic lubricating coating for the surface of medical catheters. Background technique [0002] Medical catheters need to be in contact with human tissues, blood, body fluids, etc., not only require good biocompatibility, non-toxic, and odorless, but also require smooth surfaces to reduce the friction between medical catheters and human body, which is conducive to reducing the difficulty of operation for doctors. patient's pain. [0003] The existing common medical catheters are generally coated with a hydrophilic high molecular polymer on the surface to improve the lubricating performance of the surface. Hydrophilic polymers, such as polyvinylpyrrolidone and polyvinyl alcohol, have the advantages of high hydrophilicity and strong water absorption, and can quickly hydrate in an aqueous environment to form a layer of water-swellable gel. The liquid barrier reduces the da...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L29/08A61L29/14
CPCA61L29/085A61L29/14A61L2420/06C08L39/06C08L29/04C08L79/02C08L3/08C08L33/02C08L51/006
Inventor 刘仁正谢艳红
Owner SHENZHEN XUANLI PLASTIC SCI & TECH
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