Pharmaceutical composition with synergistic effect for preventing and treating Alzheimer's disease and application

Abstract

The invention discloses a pharmaceutical composition with a synergistic effect for preventing and treating Alzheimer's disease and application. The composition is prepared from paeoniflorin and ferulic acid. An APP / PS1 transgenic dementia mouse model is selected as a research object, and experimental results show that the composition has a neuroprotective effect, can significantly improve the learning and memory ability and learning and memory retention ability of APP / PS1 transgenic dementia mice, and can be prepared into drugs for resisting Alzheimer's disease. Research finds that the composition can effectively treat the Alzheimer's disease, and the effect of remarkably improving the learning and memory ability defects can be achieved within a low dosage range.

Description

technical field [0001] The invention relates to the technical field of medicine. Specifically, it is a pharmaceutical composition and its application in medicines for preventing and treating Alzheimer's disease. Background technique [0002] Alzheimer's disease (Alzheimer disease, senile dementia) is a group of syndromes characterized by memory impairment, mental decline, personality changes and abnormal behavior. It is a syndrome in which acquired sexual cognition is the core and leads to significant decline in daily life, social interaction and work ability of patients. The survey shows that the average annual incidence rate of the elderly over 65 years old is 1% to 3%, the incidence rate of the 65-year-old person is 2.5%, and the incidence rate of the 90-year-old person reaches 85.6%. With the rapid development of social population aging and the proportion of the elderly in the population is increasing, Alzheimer's disease will become a health and social problem that ca...

AI Technical Summary

Problems solved by technology

[0006] Although previous studies have shown that paeoniflorin and ferulic acid each have a good improvement effect on central nervous system diseases, but there is low bioavailability, and the efficacy is difficult to compare with the same dose of first-line drugs

At present, there is no report on the combination of paeoniflorin and ferulic acid for the treatment of Alzheimer's disease

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