TCR-enriched clonotype as well as acquisition method and application thereof

A kind of acquisition method, clonotype technology, applied in the field of TCR enrichment clonotype and its acquisition
CN113150113AInactive Publication Date: 2021-07-23HUNAN YUANPIN CELL TECH CO LTD

Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
HUNAN YUANPIN CELL TECH CO LTD
Publication Date
2021-07-23
Estimated Expiration
Not applicable ยท inactive patent

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Abstract

The invention relates to the technical field of biological medicine, and particularly discloses a TCR-enriched clonotype as well as an acquisition method and application thereof. The amino acid sequence of the TCR-enriched clonotype is CAASAVGGAQKLVF_CATSRGTLYGYTF, and the TCR-enriched clonotype can provide specifically recognized epitopes for vaccine development, so that the TCR-enriched clonotype can be used for guiding vaccine development and providing direction and theoretical basis for vaccine development and research.
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Description

technical field

[0001] The invention relates to the technical field of biomedicine, in particular to a TCR-enriched clonotype and its acquisition method and application. Background technique

[0002] The outbreak of novel coronavirus (2019-novel coronavirus, 2019-nCoV) infection poses a serious threat to global public health. The disease caused by 2019-nCoV was officially named COVID-19 (coronavirus disease 2019) by the World Health Organization (WHO). COVID-19 is clinically manifested as pneumonia, fever, cough, muscle pain, fatigue, diarrhea and, in severe cases, death. The WHO report shows that 2019-nCoV has caused a worldwide pandemic. Vaccination is an effective means to prevent the spread of viral infection, but there is currently no new coronavirus vaccine (hereinafter referred to as the new crown vaccine). For the rapid spread of the COVID-19 virus in the public, the current treatment is still based on supportive care. Antiviral drugs, antibodies, and vaccines aga...

Claims

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